Abstract
Since the completion of the Human Genome Project, increasing scrutiny has focused on patterns of genetic variation among global populations and their association with disease and human traits. This paper addresses emerging techniques to identify genetic differences, including admixture mapping and the use of ancestry informative markers (AIMS), towards controlling population substructure in genetic association studies. The paper discusses the need to reconcile statistical race used to determine genetic ancestry with phenotypic race in identifying and addressing ongoing health disparities among human populations. As DNA biobanking grows and standards for collecting phenotypic information are developed, clear understanding of the varied approaches to defining race and their implications will be imperative. Central to this explication will be an exploration of how genetic technologies inform current approaches to ancestry and their relevance for pharmacogenomic applications.
Keywords: DNA biobanks, genetic ancestry, health disparities, pharmacogenomics, race-based therapeutics
Current Pharmacogenomics and Personalized Medicine
Title: Defining Statistical Race and Phenotypic Race and Their Implications for Health Disparities
Volume: 7 Issue: 4
Author(s): S. S-J. Lee
Affiliation:
Keywords: DNA biobanks, genetic ancestry, health disparities, pharmacogenomics, race-based therapeutics
Abstract: Since the completion of the Human Genome Project, increasing scrutiny has focused on patterns of genetic variation among global populations and their association with disease and human traits. This paper addresses emerging techniques to identify genetic differences, including admixture mapping and the use of ancestry informative markers (AIMS), towards controlling population substructure in genetic association studies. The paper discusses the need to reconcile statistical race used to determine genetic ancestry with phenotypic race in identifying and addressing ongoing health disparities among human populations. As DNA biobanking grows and standards for collecting phenotypic information are developed, clear understanding of the varied approaches to defining race and their implications will be imperative. Central to this explication will be an exploration of how genetic technologies inform current approaches to ancestry and their relevance for pharmacogenomic applications.
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Cite this article as:
Lee S-J. S., Defining Statistical Race and Phenotypic Race and Their Implications for Health Disparities, Current Pharmacogenomics and Personalized Medicine 2009; 7 (4) . https://dx.doi.org/10.2174/187569209790112300
DOI https://dx.doi.org/10.2174/187569209790112300 |
Print ISSN 1875-6921 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6913 |
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