Abstract
The introduction of oxygen atoms into different positions of the vitamin D side chain is described. By combining the arising 23-oxa and 25-oxa elements with other structural modifications (19-nor, iso-19-nor, 20-methyl, 20-ene, 20,21-cyclo) calcitriol analogs with remarkable levels of dissociation between beneficial acitivities on cell growth regulation and undesired hypercalcemia were identified. Structure-activity relations are elaborated in a very systematic outline of the Schering drug finding program in this particular class of vitamin D compounds.
Keywords: Antiproliferative Activities, 23 Oxa Calcitriols, 19 Nor 23 oxa Calcitriols, Iso 19 nor 23 oxa Calcitriols, 20 Methyl 23 oxa calcitriols, 20 Ene 23 oxa Calcitriol, 20 Ene 19 nor 23 oxa Calcitriols, 20 21 Cyclo 23 oxa calcitriols, 25 oxa Calcitriols, Relative binding affinity, Vitamin D receptor, 1 4 Diazabicyclo 2 2 2 octane, Diisobutylaluminum hydride, Vitamin D binding prtien, Human leukemia cell line, Lithium diisopropylamide
Current Pharmaceutical Design
Title: New Synthetic Vitamin D Analogs with Antiproliferative Activities
Volume: 6 Issue: 7
Author(s): Andreas Steinmeyer, Gerald Kirsch, Gunter Neef and Katica Schwarz
Affiliation:
Keywords: Antiproliferative Activities, 23 Oxa Calcitriols, 19 Nor 23 oxa Calcitriols, Iso 19 nor 23 oxa Calcitriols, 20 Methyl 23 oxa calcitriols, 20 Ene 23 oxa Calcitriol, 20 Ene 19 nor 23 oxa Calcitriols, 20 21 Cyclo 23 oxa calcitriols, 25 oxa Calcitriols, Relative binding affinity, Vitamin D receptor, 1 4 Diazabicyclo 2 2 2 octane, Diisobutylaluminum hydride, Vitamin D binding prtien, Human leukemia cell line, Lithium diisopropylamide
Abstract: The introduction of oxygen atoms into different positions of the vitamin D side chain is described. By combining the arising 23-oxa and 25-oxa elements with other structural modifications (19-nor, iso-19-nor, 20-methyl, 20-ene, 20,21-cyclo) calcitriol analogs with remarkable levels of dissociation between beneficial acitivities on cell growth regulation and undesired hypercalcemia were identified. Structure-activity relations are elaborated in a very systematic outline of the Schering drug finding program in this particular class of vitamin D compounds.
Export Options
About this article
Cite this article as:
Steinmeyer Andreas, Kirsch Gerald, Neef Gunter and Schwarz Katica, New Synthetic Vitamin D Analogs with Antiproliferative Activities, Current Pharmaceutical Design 2000; 6 (7) . https://dx.doi.org/10.2174/1381612003400470
DOI https://dx.doi.org/10.2174/1381612003400470 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Imaging and Laboratory Biomarkers in Cardiovascular Disease
Current Pharmaceutical Design Pomegranate, its Components, and Modern Deliverable Formulations as Potential Botanicals in the Prevention and Treatment of Various Cancers
Current Drug Delivery Resveratrol Pretreatment Ameliorates TNBS Colitis in Rats
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery The c-Met Inhibitors: A New Class of Drugs in the Battle Against Advanced Nonsmall- Cell Lung Cancer
Current Pharmaceutical Design Counteracting Oxidative Stress in Pregnancy through Modulation of Maternal Micronutrients and Omega-3 Fatty Acids
Current Medicinal Chemistry Modern Perspectives on the Structure, Function and Evolution of the Relaxin-Like Peptides and their Receptors
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Cardiovascular Effects of Current and Future Anti-Obesity Drugs
Current Vascular Pharmacology NK-1 Receptor Antagonists: A New Generation of Anticancer Drugs
Mini-Reviews in Medicinal Chemistry Dietary Supplementation of Curcumin Alleviates NF-κB-dependent Skeletal Muscle Wasting in Rat
Endocrine, Metabolic & Immune Disorders - Drug Targets An Intimate Alliance of DNA-Damage Response Network with Cell-Cycle Checkpoints Amid Events of Uncontrolled Cellular Proliferation: A Mini- Review
Endocrine, Metabolic & Immune Disorders - Drug Targets Nuclear Receptors: Overview and Classification
Current Drug Targets - Inflammation & Allergy Lifestyle Interventions for Cardiovascular Risk Reduction in Women with Breast Cancer
Current Cardiology Reviews Mesenchymal Stem Cell-Based Therapy for the Treatment of Type 1 Diabetes Mellitus
Current Stem Cell Research & Therapy Targeting SUMOylation Cascade for Diabetes Management
Current Drug Targets MicroRNA: Biogenesis, Function and Role in Cancer
Current Genomics Alkaloids in the Nature: Pharmacological Applications in Clinical Practice of Berberine and Mate Tea
Current Topics in Medicinal Chemistry Ethanol Extract of Achillea fragrantissima Enhances Angiogenesis through Stimulation of VEGF Production
Endocrine, Metabolic & Immune Disorders - Drug Targets Establishment of Conditionally Immortalized Cell Lines with Specific Functions and its Application to Differential Gene Expression Analysis by DNA Microarray Technology
Current Pharmaceutical Analysis The Therapeutic Target Hsp90 and Cancer Hallmarks
Current Pharmaceutical Design Synthetic Peptide Drugs for Targeting Skin Cancer: Malignant Melanoma and Melanotic Lesions
Current Medicinal Chemistry