The Mechanistic Role of Thymoquinone in Parkinson's Disease: Focus on Neuroprotection in Pre-Clinical Studies

Title:The Mechanistic Role of Thymoquinone in Parkinson's Disease: Focus on Neuroprotection in Pre-Clinical Studies

Volume: 14

Author(s): Mohammad Najim Uddin, Mohammad I. Hoq, Israt Jahan, Shafayet A. Siddiqui, Chayan D. Clinton, Mohammed Ibrahim, Mohammad S. Islam and Mohammad Jakaria*

Affiliation:

• Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC3052,Australia

Keywords: TQ, neuroprotection, neurotoxicity, neurodegeneration, dopaminergic neurons, PD.

Abstract: Thymoquinone (TQ) is one of the leading phytochemicals, which is abundantly found in Nigella sativa L. seeds. TQ exhibited various biological effects such as antioxidant, anti-inflammatory, antimicrobial, and anti-tumoral in several pre-clinical studies. Parkinson's disease (PD) is a long-term neurodegenerative disease with movement difficulties, and the common feature of neurodegeneration in PD patients is caused by dopaminergic neural damage in the substantia nigra pars compacta. The neuroprotective activity of TQ has been studied in various neurological disorders. TQ-mediated neuroprotection against PD is yet to be reported in a single frame; therefore, this review is intended to narrate the potentiality of TQ in the therapy of PD. TQ has been shown to protect against neurotoxins via amelioration of neuroinflammation, oxidative stress, and apoptosis, thereby protecting neurodegeneration in PD models. TQ could be an emerging therapeutic intervention in PD management, but mechanistic studies remain to be investigated to clarify its neuroprotective role.

Cite this article as:

Uddin Najim Mohammad , Hoq I. Mohammad , Jahan Israt, Siddiqui A. Shafayet , Clinton D. Chayan , Ibrahim Mohammed, Islam S. Mohammad and Jakaria Mohammad*, The Mechanistic Role of Thymoquinone in Parkinson's Disease: Focus on Neuroprotection in Pre-Clinical Studies, Current Molecular Pharmacology 2021; 14 (6) . https://dx.doi.org/10.2174/1874467214666210105140944