Abstract
The recent coronavirus disease (COVID-19) pandemic outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its rapid spread from continent to continent pose a global health emergency. Researchers are making headway to combat the ongoing COVID-19 to prevent further losses. Many natural antiviral compounds have been explored for their potential application in treating viral infections, including those caused by SARS- and MERS-CoV. This review focuses on natural compounds that have been showing promising results against SARS-CoV, SARS-CoV-2 and MERS-CoV, along with their mechanism of action. The entry and replication of CoV are among the major mechanism for the spread of COVID-19. In this context, natural compounds inhibiting the proteins essential for SARS-CoV-2 entry and replication in the nanomolar (nicotianamine) and micromolar (baicalin, baicalein, scutellarein, dihydromyricetin, quercetagetin, myricetin, amentoflavone, herbacetin, isobavachalcone, quercetin 3‐β‐d‐glucoside, helichrysetin, hirsutenone, hirsutanonol, oregonin, rubranol, rubranoside B, rubranoside A, tanshinones, emodin, and griffithsin) concentration could be potential sources of new anti-SARS-CoV-2 drugs.
Keywords: COVID-19, SARS-CoV-2, 2019-nCoV, SARS-CoV, MERS-CoV, natural products, antiviral drugs, traditional Chinese medicine
Current Traditional Medicine
Title:Prospects of Antiviral Drugs Derived from Natural Products: Targeting SARS-CoV Entry and Replication
Volume: 7 Issue: 5
Author(s): Tsuey Ning Soon, Wei Hsum Yap, Ya Chee Lim, Chiau Ming Long, Bey Hing Goh*Yin-Quan Tang*
Affiliation:
- College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058,China
- School of Biosciences, Faculty of Medical and Health Sciences, Taylor’s University, 47500 Subang Jaya, Selangor Darul Ehsan,Malaysia
Keywords: COVID-19, SARS-CoV-2, 2019-nCoV, SARS-CoV, MERS-CoV, natural products, antiviral drugs, traditional Chinese medicine
Abstract: The recent coronavirus disease (COVID-19) pandemic outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its rapid spread from continent to continent pose a global health emergency. Researchers are making headway to combat the ongoing COVID-19 to prevent further losses. Many natural antiviral compounds have been explored for their potential application in treating viral infections, including those caused by SARS- and MERS-CoV. This review focuses on natural compounds that have been showing promising results against SARS-CoV, SARS-CoV-2 and MERS-CoV, along with their mechanism of action. The entry and replication of CoV are among the major mechanism for the spread of COVID-19. In this context, natural compounds inhibiting the proteins essential for SARS-CoV-2 entry and replication in the nanomolar (nicotianamine) and micromolar (baicalin, baicalein, scutellarein, dihydromyricetin, quercetagetin, myricetin, amentoflavone, herbacetin, isobavachalcone, quercetin 3‐β‐d‐glucoside, helichrysetin, hirsutenone, hirsutanonol, oregonin, rubranol, rubranoside B, rubranoside A, tanshinones, emodin, and griffithsin) concentration could be potential sources of new anti-SARS-CoV-2 drugs.
Export Options
About this article
Cite this article as:
Soon Ning Tsuey , Yap Hsum Wei, Lim Chee Ya , Long Ming Chiau , Goh Hing Bey *, Tang Yin-Quan *, Prospects of Antiviral Drugs Derived from Natural Products: Targeting SARS-CoV Entry and Replication, Current Traditional Medicine 2021; 7 (5) : e220121190624 . https://dx.doi.org/10.2174/2215083807666210122151039
DOI https://dx.doi.org/10.2174/2215083807666210122151039 |
Print ISSN 2215-0838 |
Publisher Name Bentham Science Publisher |
Online ISSN 2215-0846 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Scabies: A Neglected Global Disease
Current Pediatric Reviews Nanoformulation-based Drug Delivery System for Viral Diseases
Pharmaceutical Nanotechnology Effects of Nanosuspension Formulations on Transport, Pharmacokinetics, In Vivo Targeting and Efficacy for Poorly Water-soluble Drugs
Current Pharmaceutical Design ADAM Metalloproteinases as Potential Drug Targets
Current Medicinal Chemistry DOK3 Degradation is Required for the Development of LPS-induced ARDS in Mice
Current Gene Therapy Gastrin: An Acid-Releasing, Proliferative and Immunomodulatory Peptide?
Mini-Reviews in Medicinal Chemistry 2D Chemometrics Analyses of Tetrahydroquinoline and Ethylenediamine Derivatives with Antimalarial Activity
Medicinal Chemistry A Novel Treatment Strategy for Sepsis and Septic Shock Based on the Interactions between Prostanoids, Nitric Oxide, and 20-Hydroxyeicosatetraenoic Acid
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry A Review on Repurposed Drugs and Vaccine Trials for Combating SARS CoV-2
Current Drug Research Reviews Use of Remote Sensing Techniques for Robust Digital Change Detection of Land: A Review
Recent Patents on Space Technology Gold and Silver Nanoparticles for Applications in Theranostics
Current Topics in Medicinal Chemistry The Challenges of Biomedical Waste Management During the Ongoing Coronavirus Disease-19 (COVID-19) Pandemic: The Current Scenario
Micro and Nanosystems Nanovaccine: A Hope to Triumph the Battle Against Novel Coronavirus Disease 2019 (COVID-19)
Recent Patents on Nanotechnology NMDA Receptors are not Alone: Dynamic Regulation of NMDA Receptor Structure and Function by Neuregulins and Transient Cholesterol-Rich Membrane Domains Leads to Disease-Specific Nuances of Glutamate- Signalling
Current Topics in Medicinal Chemistry Nipah Virus: An Updated Review and Emerging Challenges
Infectious Disorders - Drug Targets Factors Influencing Outcome of Patients Receiving Extracorporeal Membrane Oxygenation for Neonatal and Pediatric Respiratory Failure
Current Respiratory Medicine Reviews A Systems Medicine Clinical Platform for Understanding and Managing Non- Communicable Diseases
Current Pharmaceutical Design Thiourea-Catalyzed Asymmetric Mannich-Type Reactions
Current Organic Chemistry Obesity: The Metabolic Disease, Advances on Drug Discovery and Natural Product Research
Current Topics in Medicinal Chemistry Recent Advances on the Synthesis of Heterocycles from Diazo Compounds
Current Organic Chemistry