Amidst Cytokine Storm in Metabolic Diseases: Can 2-deoxy-D-glucose (2-DG) Cure COVID-19?

Title:Amidst Cytokine Storm in Metabolic Diseases: Can 2-deoxy-D-glucose (2-DG) Cure COVID-19?

Volume: 5 Issue: 2

Author(s): Shweta Shrivastava, Ayush Kumar, Manish Kumar Jeengar, Elsy Xavier and Prashant Tiwari*

Affiliation:

• College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, Karnataka, 560111, India

Keywords: SARS-CoV-2, COVID-19, 2-deoxy-D-glucose, metabolic disease, spike protein dynamics, aerobic glycolysis.

Abstract: The SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2)-related pandemic disease COVID-19, which began in China in 2019, became the leading cause of fatalities globally. The transmission rate of the virus is directly proportional to the so-called ‘dance dynamic’ energy of the spike protein as this phenomenon favours the ligand-receptor binding. The clinical spectrum of the COVID-19 disease, which includes (inflammation, cytokine storm, and multi-organ dysfunction), puts Corona Warriors active in various aspects of the disease, such as the efficient management of critically ill COVID-19 patients, in danger of losing their lives. Due to its effects on an ancient oxygen- independent glycolytic pathway, anti-inflammatory properties, and competitive interaction with viral proteins, 2-deoxy-D-glucose (2-DG), which is being developed in India at the Defence Research and Development Organization (DRDO), has emerged as a ground-breaking agent for COVID-19 treatment. After a virus gains entry into host cells, it is found that metabolic reprogramming takes place to meet the nutritional and energy requirements for virus reproduction. The recent approval of 2-DG for adjunctive emergency usage by the Drug Controller General of India (DCGI) may mark a turning point in the management of mild to moderate COVID-19 infection.

Cite this article as:

Shrivastava Shweta, Kumar Ayush, Kumar Jeengar Manish, Xavier Elsy and Tiwari Prashant*, Amidst Cytokine Storm in Metabolic Diseases: Can 2-deoxy-D-glucose (2-DG) Cure COVID-19?, Coronaviruses 2024; 5 (2) : e271023222860 . https://dx.doi.org/10.2174/0126667975246836231019052126