Antipsychotics in Alzheimer’s Disease: Current Status and Therapeutic Alternatives

Title:Antipsychotics in Alzheimer’s Disease: Current Status and Therapeutic Alternatives

Volume: 20 Issue: 10

Author(s): Maria Paula Maziero*, Natalia P. Rocha and Antonio L. Teixeira

Affiliation:

• Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Texas 77030, USA

Keywords: Alzheimer’s disease, psychosis, agitation, antipsychotics, hyperactive behaviors, neuropsychiatric symptoms.

Abstract: Psychosis and hyperactive behaviors, such as agitation and wandering, affect a significant proportion of patients with Alzheimer’s disease (AD). These symptoms are often treated with antipsychotics, usually in an off-label approach. This mini-review provides an updated perspective on the pharmacological approach for the neuropsychiatric symptoms (NPS) in AD. The results of new studies have provided a better understanding of AD-related NPS management, but high-quality evidence still needs to be obtained. Herein, we argue for a more cautious approach to the use of antipsychotics in AD and highlight the importance of exploring alternative treatments for NPS. By doing so, we can ensure that patients with AD receive optimal care that is both effective and safe.

Cite this article as:

Maziero Paula Maria*, Rocha P. Natalia and Teixeira L. Antonio, Antipsychotics in Alzheimer’s Disease: Current Status and Therapeutic Alternatives, Current Alzheimer Research 2023; 20 (10) . https://dx.doi.org/10.2174/0115672050287534240215052417