Antipsychotics in Alzheimer’s Disease: Current Status and Therapeutic
Alternatives

doi:10.2174/0115672050287534240215052417

摘要

精神病和多动行为，如躁动和徘徊，影响了很大比例的阿尔茨海默病(AD)患者。这些症状通常用抗精神病药物治疗，通常是在标签外的方法。这篇小型综述提供了阿尔茨海默病神经精神症状(NPS)药理学方法的最新观点。新的研究结果提供了更好的了解与广告相关的NPS管理，但仍需要获得高质量的证据。在此，我们主张在阿尔茨海默病中使用更谨慎的抗精神病药物，并强调探索NPS替代治疗方法的重要性。通过这样做，我们可以确保AD患者得到既有效又安全的最佳护理。

关键词: 阿尔茨海默病，精神病，躁动，抗精神病药物，多动行为，神经精神症状。

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Current Alzheimer Research

Title:Antipsychotics in Alzheimer’s Disease: Current Status and Therapeutic Alternatives

Volume: 20 Issue: 10

关键词: 阿尔茨海默病，精神病，躁动，抗精神病药物，多动行为，神经精神症状。

摘要: Psychosis and hyperactive behaviors, such as agitation and wandering, affect a significant proportion of patients with Alzheimer’s disease (AD). These symptoms are often treated with antipsychotics, usually in an off-label approach. This mini-review provides an updated perspective on the pharmacological approach for the neuropsychiatric symptoms (NPS) in AD. The results of new studies have provided a better understanding of AD-related NPS management, but high-quality evidence still needs to be obtained. Herein, we argue for a more cautious approach to the use of antipsychotics in AD and highlight the importance of exploring alternative treatments for NPS. By doing so, we can ensure that patients with AD receive optimal care that is both effective and safe.

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Cite this article as:

Antipsychotics in Alzheimer’s Disease: Current Status and Therapeutic Alternatives, Current Alzheimer Research 2023; 20 (10) . https://dx.doi.org/10.2174/0115672050287534240215052417

DOI https://dx.doi.org/10.2174/0115672050287534240215052417	Print ISSN 1567-2050
Publisher Name Bentham Science Publisher	Online ISSN 1875-5828

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