Abstract
Ribonucleotide reductase (RNR) is the key enzyme in the biosynthesis of deoxyribonucleotides. Several different strategies for inactivation of RNRs have been reported, including the use of substrate analogues as mechanism-based inhibitors. This article undergoes a critical analysis on the current status of ribonucleotide reductase inhibitory mechanisms by substrate analogues highlighting experimental and theoretical/computational approaches. We have summarized a general portrait of the inhibitory mechanisms and classified the nucleoside analogue inhibitors in three main classes. The critical analysis undertaken will contribute in finding new and more effective ways of inhibiting RNR.
Keywords: Ribonucleotide reductase, RNR, substrate analogues, gemcitabine, inhibitors, computational chemistry, density functional theory
Current Medicinal Chemistry
Title: Ribonucleotide Reductase: A Mechanistic Portrait of Substrate Analogues Inhibitors
Volume: 17 Issue: 26
Author(s): M.A.S. Perez, N.M.F.S.A. Cerqueira, P.A. Fernandes and M.J. Ramos
Affiliation:
Keywords: Ribonucleotide reductase, RNR, substrate analogues, gemcitabine, inhibitors, computational chemistry, density functional theory
Abstract: Ribonucleotide reductase (RNR) is the key enzyme in the biosynthesis of deoxyribonucleotides. Several different strategies for inactivation of RNRs have been reported, including the use of substrate analogues as mechanism-based inhibitors. This article undergoes a critical analysis on the current status of ribonucleotide reductase inhibitory mechanisms by substrate analogues highlighting experimental and theoretical/computational approaches. We have summarized a general portrait of the inhibitory mechanisms and classified the nucleoside analogue inhibitors in three main classes. The critical analysis undertaken will contribute in finding new and more effective ways of inhibiting RNR.
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Cite this article as:
Perez M.A.S., Cerqueira N.M.F.S.A., Fernandes P.A. and Ramos M.J., Ribonucleotide Reductase: A Mechanistic Portrait of Substrate Analogues Inhibitors, Current Medicinal Chemistry 2010; 17 (26) . https://dx.doi.org/10.2174/092986710792065054
DOI https://dx.doi.org/10.2174/092986710792065054 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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