Abstract
Mastocytosis or mast cell disease represents a clonal, neoplastic proliferation of mast cells that can present in one or multiple organs, varying from indolent to aggressive disorders in adult and pediatric patients. This review presents the definition of the various forms of mastocytosis along with the characteristic cytomorphological, immunophenotypic, cytogenetic, and molecular features and discusses in depth the differential diagnoses. Following this presentation, the review then focuses on therapeutic approaches, including targeted therapy.
Keywords: Mastocytosis, D816V KIT
Current Cancer Therapy Reviews
Title: Mastocytosis
Volume: 8 Issue: 1
Author(s): Tracy I. George
Affiliation:
Keywords: Mastocytosis, D816V KIT
Abstract: Mastocytosis or mast cell disease represents a clonal, neoplastic proliferation of mast cells that can present in one or multiple organs, varying from indolent to aggressive disorders in adult and pediatric patients. This review presents the definition of the various forms of mastocytosis along with the characteristic cytomorphological, immunophenotypic, cytogenetic, and molecular features and discusses in depth the differential diagnoses. Following this presentation, the review then focuses on therapeutic approaches, including targeted therapy.
Export Options
About this article
Cite this article as:
I. George Tracy, Mastocytosis, Current Cancer Therapy Reviews 2012; 8 (1) . https://dx.doi.org/10.2174/157339412799462549
DOI https://dx.doi.org/10.2174/157339412799462549 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Biomarkers for Colorectal Cancer: Identification Through Proteomics
Current Proteomics Roles of SUMOylation in Heart Development and Cardiovascular Diseases
Current Molecular Medicine The Role of MRI in Treatment Planning for Rectal Cancer - A Review
Current Cancer Therapy Reviews Flavonoids as Anticancer Agents: Recent Progress and State of the Art?
Current Organic Chemistry Phytochemical Informatics and Virtual Screening of Herbs Used in Chinese Medicine
Current Pharmaceutical Design Drug Transporters and Multiple Drug Resistance in the Most Common Pediatric Solid Tumors
Current Drug Metabolism Vertebrae Segmentation in 3D CT Data: A Review of Methods and Evaluation Approaches
Current Medical Imaging p38 MAP Kinase Interacts with and Stabilizes Pancreatic and Duodenal Homeobox-1
Current Molecular Medicine Proteomic Validation of Protease Drug Targets: Pharmacoproteomics of Matrix Metalloproteinase Inhibitor Drugs Using Isotope-Coded Affinity Tag Labelling and Tandem Mass Spectrometry
Current Pharmaceutical Design Structural and Functional Diversity of Estrogen Receptor Ligands
Current Topics in Medicinal Chemistry Pharmacological Control of Autophagy: Therapeutic Perspectives in Inflammatory Bowel Disease and Colorectal Cancer
Current Pharmaceutical Design Toxicities by Herbal Medicines with Emphasis to Traditional Chinese Medicine
Current Drug Metabolism Microfluidic Assembly of Lipid Nanoparticles for Delivery of Antisense Oligonucleotides
Current Pharmaceutical Biotechnology Radiosensitization of Prostate Cancer by Soy Isoflavones
Current Cancer Drug Targets Subcellular Accumulation and Modification of Pharmaceutical Proteins in Different Plant Tissues
Current Pharmaceutical Design A Review of Studies on Targeting Interleukin 4 Receptor for Central Nervous System Malignancy
Current Molecular Medicine Barminomycin, a Model for the Development of New Anthracyclines
Anti-Cancer Agents in Medicinal Chemistry PET Imaging of the Peripheral Benzodiazepine Receptor: Monitoring Disease Progression and Therapy Response in Neurodegenerative Disorders
Current Pharmaceutical Design Molecular Approach to Targeted Therapy for Multiple Sclerosis
CNS & Neurological Disorders - Drug Targets Can Untargeted Metabolomics Be Utilized in Drug Discovery/Development?
Current Topics in Medicinal Chemistry