Abstract
Coronary artery disease (CAD) is the leading cause of mortality in Western Societies and several developing countries. Recent evidence suggests that most detrimental clinical manifestations of CAD, such as acute coronary syndromes (ACS), are the outcome of inflammatory processes that lead to plaque formation and rupture and eventually to ischemia and potentially myocardial necrosis. Neither of the traditionally used biomarkers is thought to be the gold standard in detection of myocardial ischemia or necrosis. A biomarker that could detect quite early the ischemic myocardium as well as define the risk of a future event with high sensitivity and specificity is still lacking. Several biomarkers, implicated in the pathogenesis and clinical evolution of atherosclerosis, have emerged as potent biomarkers for early detection of myocardial ischemia. In the current review, we summarize recent evidence of the most promising biomarkers and discuss their potential role in clinical practice in patients suffering from ACSs.
Keywords: Biomarkers, atherosclerosis, ischemia, acute coronary syndrome, myocardial infarction, Coronary artery disease(CAD), clinical manifestations, syndromes, inflammation, myocardial ischemia
Current Medicinal Chemistry
Title:Assessment of Acute Coronary Syndromes: Focus on Novel Biomarkers
Volume: 19 Issue: 16
Author(s): D. Tousoulis, G. Hatzis, N. Papageorgiou, E. Androulakis, G. Bouras, A. Giolis, C. Bakogiannis, G. Siasos, G. Latsios, C. Antoniades and C. Stefanadis
Affiliation:
Keywords: Biomarkers, atherosclerosis, ischemia, acute coronary syndrome, myocardial infarction, Coronary artery disease(CAD), clinical manifestations, syndromes, inflammation, myocardial ischemia
Abstract: Coronary artery disease (CAD) is the leading cause of mortality in Western Societies and several developing countries. Recent evidence suggests that most detrimental clinical manifestations of CAD, such as acute coronary syndromes (ACS), are the outcome of inflammatory processes that lead to plaque formation and rupture and eventually to ischemia and potentially myocardial necrosis. Neither of the traditionally used biomarkers is thought to be the gold standard in detection of myocardial ischemia or necrosis. A biomarker that could detect quite early the ischemic myocardium as well as define the risk of a future event with high sensitivity and specificity is still lacking. Several biomarkers, implicated in the pathogenesis and clinical evolution of atherosclerosis, have emerged as potent biomarkers for early detection of myocardial ischemia. In the current review, we summarize recent evidence of the most promising biomarkers and discuss their potential role in clinical practice in patients suffering from ACSs.
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Tousoulis D., Hatzis G., Papageorgiou N., Androulakis E., Bouras G., Giolis A., Bakogiannis C., Siasos G., Latsios G., Antoniades C. and Stefanadis C., Assessment of Acute Coronary Syndromes: Focus on Novel Biomarkers, Current Medicinal Chemistry 2012; 19 (16) . https://dx.doi.org/10.2174/092986712800493011
DOI https://dx.doi.org/10.2174/092986712800493011 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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