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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Microwave-Assisted Multicomponent Reactions of Alkyl Bromides: Synthesis of Thiophene Derivatives

Author(s): Faramarz Rostami-Charati, Asadollah Hassankhani and Zinatossadat Hossaini

Volume 15, Issue 10, 2012

Page: [822 - 825] Pages: 4

DOI: 10.2174/138620712803901162

Price: $65

Abstract

A series of thiophene derivatives were synthesized via one-pot multicomponent reactions of alkyl bromids, aroyl or alkanoyl isothiocyanates, 1,3-dicarbonyl compounds and secondary amins under microwave irradiation at 80 °C. Particularly valuable features of this method include high yields of products, broad substrate scope, short reaction time and straightforward procedure.

Keywords: Acetyl acetone, carbonyl compounds, dimedone, microwave conditions, thiophen.


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