Abstract
A series of thiophene derivatives were synthesized via one-pot multicomponent reactions of alkyl bromids, aroyl or alkanoyl isothiocyanates, 1,3-dicarbonyl compounds and secondary amins under microwave irradiation at 80 °C. Particularly valuable features of this method include high yields of products, broad substrate scope, short reaction time and straightforward procedure.
Keywords: Acetyl acetone, carbonyl compounds, dimedone, microwave conditions, thiophen.
Combinatorial Chemistry & High Throughput Screening
Title:Microwave-Assisted Multicomponent Reactions of Alkyl Bromides: Synthesis of Thiophene Derivatives
Volume: 15 Issue: 10
Author(s): Faramarz Rostami-Charati, Asadollah Hassankhani and Zinatossadat Hossaini
Affiliation:
Keywords: Acetyl acetone, carbonyl compounds, dimedone, microwave conditions, thiophen.
Abstract: A series of thiophene derivatives were synthesized via one-pot multicomponent reactions of alkyl bromids, aroyl or alkanoyl isothiocyanates, 1,3-dicarbonyl compounds and secondary amins under microwave irradiation at 80 °C. Particularly valuable features of this method include high yields of products, broad substrate scope, short reaction time and straightforward procedure.
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Cite this article as:
Rostami-Charati Faramarz, Hassankhani Asadollah and Hossaini Zinatossadat, Microwave-Assisted Multicomponent Reactions of Alkyl Bromides: Synthesis of Thiophene Derivatives, Combinatorial Chemistry & High Throughput Screening 2012; 15 (10) . https://dx.doi.org/10.2174/138620712803901162
DOI https://dx.doi.org/10.2174/138620712803901162 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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