Abstract
Nanostructured lipid carriers (NLCs) are drug-delivery systems composed of both solid and liquid lipids as a core matrix. It was shown that NLCs reveal some advantages for drug therapy over conventional carriers, including increased solubility, the ability to enhance storage stability, improved permeability and bioavailability, reduced adverse effect, prolonged half-life, and tissue-targeted delivery. NLCs have attracted increasing attention in recent years. This review describes recent developments in drug delivery using NLCs strategies. The structures, preparation techniques, and physicochemical characterization of NLCs are systematically elucidated in this review. The potential of NLCs to be used for different administration routes is highlighted. Special attention is paid to parenteral injection and topical delivery since these are the most common routes for investigating NLCs. Relevant issues for the introduction of NLCs to market, including pharmaceutical and cosmetic applications, are discussed. The related patents of NLCs for drug delivery are also reviewed. Finally, the future development and current obstacles needing to be resolved are elucidated.
Keywords: Drug targeting, lipid nanoparticles, nanostructured lipid carriers (NLCs), drug delivery
Recent Patents on Nanotechnology
Title:Nanostructured Lipid Carriers (NLCs) for Drug Delivery and Targeting
Volume: 7 Issue: 1
Author(s): Chia-Lang Fang, Saleh A. Al-Suwayeh and Jia-You Fang
Affiliation:
Keywords: Drug targeting, lipid nanoparticles, nanostructured lipid carriers (NLCs), drug delivery
Abstract: Nanostructured lipid carriers (NLCs) are drug-delivery systems composed of both solid and liquid lipids as a core matrix. It was shown that NLCs reveal some advantages for drug therapy over conventional carriers, including increased solubility, the ability to enhance storage stability, improved permeability and bioavailability, reduced adverse effect, prolonged half-life, and tissue-targeted delivery. NLCs have attracted increasing attention in recent years. This review describes recent developments in drug delivery using NLCs strategies. The structures, preparation techniques, and physicochemical characterization of NLCs are systematically elucidated in this review. The potential of NLCs to be used for different administration routes is highlighted. Special attention is paid to parenteral injection and topical delivery since these are the most common routes for investigating NLCs. Relevant issues for the introduction of NLCs to market, including pharmaceutical and cosmetic applications, are discussed. The related patents of NLCs for drug delivery are also reviewed. Finally, the future development and current obstacles needing to be resolved are elucidated.
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Cite this article as:
Fang Chia-Lang, A. Al-Suwayeh Saleh and Fang Jia-You, Nanostructured Lipid Carriers (NLCs) for Drug Delivery and Targeting, Recent Patents on Nanotechnology 2013; 7 (1) . https://dx.doi.org/10.2174/1872210511307010041
DOI https://dx.doi.org/10.2174/1872210511307010041 |
Print ISSN 1872-2105 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4020 |
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