Abstract
Nonalcoholic fatty liver disease (NAFLD) is among the most common causes of chronic liver disease in the westernized world and now represents a worldwide public health problem. NAFLD encompasses a broad spectrum of conditions, ranging from simple steatosis (nonalcoholic fatty liver) to nonalcoholic steatohepatitis (NASH). The latter is recognized as a potentially progressive disease that could lead to cirrhosis, liver failure, and hepatocellular carcinoma. The recent rise in obesity likely explains the NAFLD epidemic worldwide. Recognition of the importance of NAFLD and its strong association with metabolic syndrome has stimulated interest in its putative role in the development of cardiovascular disease (CVD). Recently, accumulating evidence suggests that NAFLD is associated with a significant greater overall mortality, as well as with increased prevalence of CVD, both of which are independent of classical atherosclerotic risk factors. Furthermore, observation studies of natural history of NAFLD have shown that increased age-related mortality of NAFLD patients is attributable to CVD and liver-related diseases such as liver failure and hepatocellular carcinoma. In this paper, we review clinical data to support a strong association between NAFLD and CVD, and discuss possible underlying mechanisms for accelerated atherosclerosis in NAFLD.
Keywords: Nonalcoholic fatty liver disease, cardiovascular disease, atherosclerosis.
Current Pharmaceutical Design
Title:Nonalcoholic Fatty Liver Disease and Cardiovascular Disease
Volume: 20 Issue: 14
Author(s): Hideyuki Hyogo, Kazuaki Chayama and Sho-ichi Yamagishi
Affiliation:
Keywords: Nonalcoholic fatty liver disease, cardiovascular disease, atherosclerosis.
Abstract: Nonalcoholic fatty liver disease (NAFLD) is among the most common causes of chronic liver disease in the westernized world and now represents a worldwide public health problem. NAFLD encompasses a broad spectrum of conditions, ranging from simple steatosis (nonalcoholic fatty liver) to nonalcoholic steatohepatitis (NASH). The latter is recognized as a potentially progressive disease that could lead to cirrhosis, liver failure, and hepatocellular carcinoma. The recent rise in obesity likely explains the NAFLD epidemic worldwide. Recognition of the importance of NAFLD and its strong association with metabolic syndrome has stimulated interest in its putative role in the development of cardiovascular disease (CVD). Recently, accumulating evidence suggests that NAFLD is associated with a significant greater overall mortality, as well as with increased prevalence of CVD, both of which are independent of classical atherosclerotic risk factors. Furthermore, observation studies of natural history of NAFLD have shown that increased age-related mortality of NAFLD patients is attributable to CVD and liver-related diseases such as liver failure and hepatocellular carcinoma. In this paper, we review clinical data to support a strong association between NAFLD and CVD, and discuss possible underlying mechanisms for accelerated atherosclerosis in NAFLD.
Export Options
About this article
Cite this article as:
Hyogo Hideyuki, Chayama Kazuaki and Yamagishi Sho-ichi, Nonalcoholic Fatty Liver Disease and Cardiovascular Disease, Current Pharmaceutical Design 2014; 20 (14) . https://dx.doi.org/10.2174/13816128113199990476
DOI https://dx.doi.org/10.2174/13816128113199990476 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Lentinus edodes: A Macrofungus with Pharmacological Activities
Current Medicinal Chemistry Prayer at Midlife is Associated with Reduced Risk of Cognitive Decline in Arabic Women
Current Alzheimer Research Future Prospects in Anti-Platelet Therapy: A Review of Potential P2Y12 and Thrombin Receptor Antagonists
Recent Patents on Cardiovascular Drug Discovery Anti-Atherosclerotic Molecules Targeting Oxidative Stress and Inflammation
Current Pharmaceutical Design Global Account of Barriers and Facilitators of Physical Activity Among Patients with Diabetes Mellitus: A Narrative Review of the Literature
Current Diabetes Reviews Human Use of Leucoselect® Phytosome® with Special Reference to Inflammatory- Allergic Pathologies in Frail Elderly Patients
Current Pharmaceutical Design Fatty Acid-Mediated Inhibition of Metal Binding to the Multi-Metal Site on Serum Albumin: Implications for Cardiovascular Disease
Current Topics in Medicinal Chemistry Pharmacogenetics of the Antiplatelet Effect of Aspirin
Current Pharmaceutical Design A Comprehensive Review of the Genus Pyrola Herbs in Traditional Uses, Phytochemistry and Pharmacological Activities
Current Topics in Medicinal Chemistry Medicinal Plants as Potential Sources of Lead Compounds with Anti-Platelet and Anti-Coagulant Activ
Mini-Reviews in Medicinal Chemistry The Effect of Anti-B-cell Therapy on the Development of Atherosclerosis in Patients with Rheumatoid Arthritis
Current Pharmaceutical Design Epidemiology and Natural History of Patients with NAFLD
Current Pharmaceutical Design Renal Phosphate Handling in Antiretroviral-naive HIV-Infected Patients
Infectious Disorders - Drug Targets Role of Antioxidants in Redox Regulation of Diabetic Cardiovascular Complications
Current Pharmaceutical Biotechnology Aptamers in Drug Design: An Emerging Weapon to Fight a Losing Battle
Current Drug Targets Obesity-Driven Inflammation and Colorectal Cancer
Current Medicinal Chemistry Natural Products Based Ayurvedic Formulations: Chemical Cons tituents and Treatment in Neurodegenerative Disordersǂ
Mini-Reviews in Organic Chemistry Green Tea Catechins and Cardiovascular Health: An Update
Current Medicinal Chemistry α-Melanocyte Stimulating Hormone as a Potential Therapy for Alzheimer's Disease
Current Alzheimer Research Unconventional Players on the Striated Muscle Field: microRNAs, Signaling Pathways and Epigenetic Regulators
Current Stem Cell Research & Therapy