Abstract
Saccharide arrays are powerful tools to investigate the saccharide-mediated recognition events in highthroughput mode. Many methods have been used to immobilize the saccharides on support surface in the array format. The array-based technologies were widely utilized to analyze the characters of saccharide-binding lectins and antibodies, quantitatively determine saccharide-protein interactions, detect cells and pathogens, identify disease-related antisaccharide antibodies for diagnosis, and fast assess substrate specificities of glycosyltransferases. This review has mainly summarized the fabrication methods of saccharide arrays and their applications in recent years.
Keywords: Saccharide arrays, Polysaccharide arrays, Oligosaccharide arrays, Saccharide-binding lectins and antibodies, Saccharide-protein interactions, Glycosyltransferases, Fabrication, Applications.
Mini-Reviews in Medicinal Chemistry
Title:An Update on Saccharide Arrays
Volume: 13 Issue: 11
Author(s): Gangliang Huang, Yingxue Zhang and Hong Xu
Affiliation:
Keywords: Saccharide arrays, Polysaccharide arrays, Oligosaccharide arrays, Saccharide-binding lectins and antibodies, Saccharide-protein interactions, Glycosyltransferases, Fabrication, Applications.
Abstract: Saccharide arrays are powerful tools to investigate the saccharide-mediated recognition events in highthroughput mode. Many methods have been used to immobilize the saccharides on support surface in the array format. The array-based technologies were widely utilized to analyze the characters of saccharide-binding lectins and antibodies, quantitatively determine saccharide-protein interactions, detect cells and pathogens, identify disease-related antisaccharide antibodies for diagnosis, and fast assess substrate specificities of glycosyltransferases. This review has mainly summarized the fabrication methods of saccharide arrays and their applications in recent years.
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Cite this article as:
Huang Gangliang, Zhang Yingxue and Xu Hong, An Update on Saccharide Arrays, Mini-Reviews in Medicinal Chemistry 2013; 13 (11) . https://dx.doi.org/10.2174/13895575113139990068
DOI https://dx.doi.org/10.2174/13895575113139990068 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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