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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

An Update on Saccharide Arrays

Author(s): Gangliang Huang, Yingxue Zhang and Hong Xu

Volume 13, Issue 11, 2013

Page: [1656 - 1663] Pages: 8

DOI: 10.2174/13895575113139990068

Price: $65

Abstract

Saccharide arrays are powerful tools to investigate the saccharide-mediated recognition events in highthroughput mode. Many methods have been used to immobilize the saccharides on support surface in the array format. The array-based technologies were widely utilized to analyze the characters of saccharide-binding lectins and antibodies, quantitatively determine saccharide-protein interactions, detect cells and pathogens, identify disease-related antisaccharide antibodies for diagnosis, and fast assess substrate specificities of glycosyltransferases. This review has mainly summarized the fabrication methods of saccharide arrays and their applications in recent years.

Keywords: Saccharide arrays, Polysaccharide arrays, Oligosaccharide arrays, Saccharide-binding lectins and antibodies, Saccharide-protein interactions, Glycosyltransferases, Fabrication, Applications.


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