Abstract
As the most common neurodegenerative disease, therapeutic avenues for the treatment and prevention of Alzheimer’s Disease are highly sought after. The aspartic protease BACE1 is the initiator enzyme for the formation of Aβ, a major constituent of amyloid plaques that represent one of the hallmark pathological features of this disorder. Thus, targeting BACE1 for disease-modifying AD therapies represents a rationale approach. The collective knowledge acquired from investigations of BACE1 deletion mutants and characterization of BACE1 substrates has downstream significance not only for the discovery of AD drug therapies but also for predicting side effects of BACE1 inhibition. Here we discuss the identification and validation of BACE1 as the β-secretase implicated in AD, in addition to information regarding BACE1 cell biology, localization, substrates and potential physiological functions derived from BACE1 knockout models.
Keywords: Alzheimer’s disease, BACE1, beta-secretase.
Current Alzheimer Research
Title:The Normal and Pathologic Roles of the Alzheimer's β-secretase, BACE1
Volume: 11 Issue: 5
Author(s): Patty C. Kandalepas and Robert Vassar
Affiliation:
Keywords: Alzheimer’s disease, BACE1, beta-secretase.
Abstract: As the most common neurodegenerative disease, therapeutic avenues for the treatment and prevention of Alzheimer’s Disease are highly sought after. The aspartic protease BACE1 is the initiator enzyme for the formation of Aβ, a major constituent of amyloid plaques that represent one of the hallmark pathological features of this disorder. Thus, targeting BACE1 for disease-modifying AD therapies represents a rationale approach. The collective knowledge acquired from investigations of BACE1 deletion mutants and characterization of BACE1 substrates has downstream significance not only for the discovery of AD drug therapies but also for predicting side effects of BACE1 inhibition. Here we discuss the identification and validation of BACE1 as the β-secretase implicated in AD, in addition to information regarding BACE1 cell biology, localization, substrates and potential physiological functions derived from BACE1 knockout models.
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Cite this article as:
Kandalepas C. Patty and Vassar Robert, The Normal and Pathologic Roles of the Alzheimer's β-secretase, BACE1, Current Alzheimer Research 2014; 11 (5) . https://dx.doi.org/10.2174/1567205011666140604122059
DOI https://dx.doi.org/10.2174/1567205011666140604122059 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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