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Current Chemical Biology


ISSN (Print): 2212-7968
ISSN (Online): 1872-3136

Biosynthetic Pathways to Glycosidase Inhibitors

Author(s): Fernando Gomollon-Bel, Ignacio Delso, Tomas Tejero and Pedro Merino

Volume 8, Issue 1, 2014

Page: [10 - 16] Pages: 7

DOI: 10.2174/221279680801141112094818

Price: $65


Glycosidase inhibitors are important compounds that can interfere with several biosynthetic processes including N-linked glycosylation and the biosynthesis of several glycoproteins. Understanding the biogenesis of naturally occurring glycosidase inhibitors would be a crucial step towards the chemical synthesis of analogues of choice. This review focuses on the current knowledge regarding the biosynthesis of a series of polyhydroxylated saturated nitrogen heterocycles including nojirimycin and swainsonine among others, with a potent biological activity as inhibitors of glycosidases and transglycosidases.

Keywords: Biosynthesis, deoxynojirimycin, glycosidase inhibitors, nojirimycin, swainsonine.

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