摘要
已报道老年痴呆症率具有种族差异,虽然大多数研究都没有注意精细的测量结果,由于教育或其他人口因素混杂,他们也没有研究出除痴呆症之外的其他成果。在这篇综述中,我们将讨论在社区动脉粥样硬化风险(ARIC)的实验,其用于评估与中风,亚临床型脑梗塞,脑白质,以及认知改变和痴呆相关的风险。研究人群是来自美国四个社区,最初从1987-1989年收集的,并有5人次的观测(大部分是在2011-2013年)共15,792名参与者。我们从ARIC研究提供证据,认为不成比例的血管危险因素至少在一些种族差异中可观察到,但特殊的风险因素,如糖尿病,可能会影响非裔美国人与白人参与者的大脑差异。此外,我们将重点研究在遗传性中风,小血管病变和痴呆中的种族差异。
关键词: 脑MRI,认知,痴呆,流行病学,种族差异。
Current Alzheimer Research
Title:Brain Aging in African-Americans: The Atherosclerosis Risk in Communities (ARIC) Experience
Volume: 12 Issue: 7
Author(s): Rebecca F. Gottesman, Myriam Fornage, David S. Knopman and Thomas H. Mosley
Affiliation:
关键词: 脑MRI,认知,痴呆,流行病学,种族差异。
摘要: Reported rates of dementia differ by race, although most studies have not focused on carefully measured outcomes, confounding by education or other demographic factors, nor have they studied other outcomes other than dementia. In this review we will discuss the experience in the Atherosclerosis Risk in Communities (ARIC) study evaluating racial disparities relating to stroke, subclinical brain infarction, leukoaraiosis, as well as cognitive change and dementia. ARIC is a biracial cohort of 15,792 participants from four U.S. communities, initially recruited in 1987-1989, and seen at a total of 5 in-person visits (most recently seen in 2011-2013) with annual follow-up phone calls. We will provide evidence from ARIC studies that disproportionate rates of vascular risk factors explain at least some of these observed disparities by race, but particular risk factors, including diabetes, may differentially affect the brain in African-American versus white participants. In addition, we will review some of the disparities by race in studies focusing on the genetics of stroke, small vessel disease, and dementia.
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Rebecca F. Gottesman, Myriam Fornage, David S. Knopman and Thomas H. Mosley , Brain Aging in African-Americans: The Atherosclerosis Risk in Communities (ARIC) Experience, Current Alzheimer Research 2015; 12 (7) . https://dx.doi.org/10.2174/1567205012666150701102445
DOI https://dx.doi.org/10.2174/1567205012666150701102445 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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