摘要
黄酮广泛存在于日常食用的水果和蔬菜的次生代谢产物。它们具有不同的性质,例如抗炎,抗氧化和抗癌。流行病学研究表明,富集黄酮类化合物的饮食能使乳腺癌的风险降低。这些防护性能是由于所涉及的癌症相关的现象,如炎症和增殖大量信号传导途径的改变。检查补充剂对预防疾病的一些类黄酮的作用人体临床试验已经进行。没有天然黄酮被批准用于乳腺癌的治疗。但是,天然黄酮担任癌症化学预防和/或治疗剂的合成中的先导化合物。
关键词: 乳腺癌,化学预防剂,化学治疗剂,黄酮
Current Medicinal Chemistry
Title:Flavonoids, Breast Cancer Chemopreventive and/or Chemotherapeutic Agents
Volume: 22 Issue: 30
Author(s): Chantal Beatrice Magne Nde, Stephane Zingue, Evelyn Winter, Tania Beatriz Creczynski-Pasa, Thomas Michel, Xavier Fernandez and Dieudonne Njamen and Colin Clyne
Affiliation:
关键词: 乳腺癌,化学预防剂,化学治疗剂,黄酮
摘要: Flavonoids are secondary metabolites abundantly present in commonly consumed fruits and vegetables. They possess diverse properties such as anti-inflammatory, anti-oxidant and anti-cancer. Epidemiologic studies suggest that an enrich flavonoids diet is linked to a decreased risk of breast cancer. These protective properties are due to the alteration of numerous signalling pathways involved in cancer-related phenomena such as inflammation and proliferation. Human clinical trials examining the effect of supplementation of some flavonoids on disease prevention have been conducted. There is no natural flavonoid that has been approved for the treatment of breast cancer. However, natural flavonoids served as lead compounds in the synthesis of cancer chemopreventive and/or therapeutic agents.
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Chantal Beatrice Magne Nde, Stephane Zingue, Evelyn Winter, Tania Beatriz Creczynski-Pasa, Thomas Michel, Xavier Fernandez and Dieudonne Njamen and Colin Clyne , Flavonoids, Breast Cancer Chemopreventive and/or Chemotherapeutic Agents, Current Medicinal Chemistry 2015; 22 (30) . https://dx.doi.org/10.2174/0929867322666150729115321
DOI https://dx.doi.org/10.2174/0929867322666150729115321 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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