摘要
炎症是基本的保护性反应,然而,失调的免疫反应可能会导致慢性人类疾病,包括癌症。炎性细胞和介质是肿瘤微环境中必不可少的,解剖这个复杂的分子和细胞环境可能阐明了癌症和炎症之间的联系,并有助于确定潜在的新的治疗靶点。因此,关注在炎症相关的癌症中的转录因子NF-κB和κE2F1是迫切的。NF-κB的激活盛行于癌,主要由肿瘤微环境中的炎症因子驱动。E2F1还参与调节免疫应答。了解这两种途径之间的串扰可能有助于新的抗癌药物的发展。
关键词: 炎症相关的癌症,NF-κB
Current Cancer Drug Targets
Title:E2F1 and NF-κB: Key Mediators of Inflammation-associated Cancers and Potential Therapeutic Targets
Volume: 16 Issue: 9
Author(s): Yulin Huang, Rui Chen, Jianwei Zhou
Affiliation:
关键词: 炎症相关的癌症,NF-κB
摘要: Inflammation is the fundamental protective response; however disordered immuno-response can cause chronic human disease, including cancer. Inflammatory cells and mediators are essential to the tumor microenvironment and dissection of this complex molecular and cellular milieu may elucidate a connection between cancer and inflammation and help to identify potential novel therapeutic targets. Thus, focusing on transcription factor NF-κB and E2F1 in inflammation-associated cancer is urgent. NF-κB activation is prevalent in carcinomas, mainly driven by inflammatory cytokines in the tumor microenvironment. E2F1 is also involved in regulating immune responses. Understanding the crosstalk between the two pathways may contribute to the development of novel anti-cancer drugs.
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Cite this article as:
Yulin Huang, Rui Chen, Jianwei Zhou , E2F1 and NF-κB: Key Mediators of Inflammation-associated Cancers and Potential Therapeutic Targets, Current Cancer Drug Targets 2016; 16 (9) . https://dx.doi.org/10.2174/1568009616666160216130755
DOI https://dx.doi.org/10.2174/1568009616666160216130755 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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