摘要
上皮性卵巢癌(EOC)是妇科恶性肿瘤中最致命的疾病。尽管对卵巢癌的生物学认识和疗效上都有所提高,在过去的二十年里,卵巢癌患者的生存率没有改善。由于化疗耐药性的发展,晚期患者经常复发。最近在体内和体外研究表明对这种耐药性的机制的了解,包括微核糖核酸(miRNA,miR)在耐药过程的潜在作用。在这篇综述中,我们概述了当前上皮性卵巢癌与miRNA相关的化疗耐药的治疗靶点,讨论其潜在的治疗价值和miRNA影响化疗耐药的进展和逆转的分子机制。
关键词: 卵巢癌、复发、耐药性、微核糖核酸靶点,癌基因,肿瘤抑制因子。
Current Cancer Drug Targets
Title:Mechanisms and Therapeutic Targets of microRNA-associated Chemoresistance in Epithelial Ovarian Cancer
Volume: 16 Issue: 5
Author(s): Lingyun Zhang, Lubna Nadeem, Kristin Connor, Guoxiong Xu
Affiliation:
关键词: 卵巢癌、复发、耐药性、微核糖核酸靶点,癌基因,肿瘤抑制因子。
摘要: Epithelial ovarian cancer (EOC) is the most lethal disease among gynecologic malignancies. Despite increasing knowledge of ovarian cancer biology and advances in treatment efficacy, the survival rate of patients with EOC has not improved over the past two decades. Patients with an advanced disease often relapse due to the development of chemoresistance. Recent in vivo and in vitro studies have shown insight into the mechanisms of such drug resistance, including a potential role for microRNAs (miRNA, miR) in the process of chemoresistance. In this review, we provide an overview of current therapeutic targets of miRNA-associated chemoresistance in EOC and discuss potential therapeutic values and molecular mechanisms by which miRNAs influence the development and reversal of chemoresistance.
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Cite this article as:
Lingyun Zhang, Lubna Nadeem, Kristin Connor, Guoxiong Xu , Mechanisms and Therapeutic Targets of microRNA-associated Chemoresistance in Epithelial Ovarian Cancer, Current Cancer Drug Targets 2016; 16 (5) . https://dx.doi.org/10.2174/1568009616666160404121105
DOI https://dx.doi.org/10.2174/1568009616666160404121105 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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