Abstract
Background: Vitamin D is a fat soluble vitamin involved in calcium and bone metabolism; recently its deficiency has been related to cardiovascular disease. In cardiac tissue, vitamin D suppresses metalloproteinases (MMPs) expression, enzymes directly associated with vulnerable plaque.
Objective: To investigate whether the association between vitamin D and leptin is related to markers of vulnerable plaque, such as MMPs in patients with acute myocardial infarction.
Methods: We studied 66 male patients with acute myocardial infarction, undergoing primary angioplasty. Blood samples were obtained at admission and 24hs after the surgery. Leptin and vitamin D concentrations in serum and MMP-2 and -9 activities in plasma were determined.
Results: MMP-2 activity was increased in Vitamin D deficient/insufficient patients at admission (p=0.04) and 24 hs later (p=0.05). In a linear regression model, vitamin D explained 24% of the variance of MMP-2 activity (F=2.839 p=0.04). At admission, vitamin D correlated with serum leptin (r=-0.302 p=0.033), and explained 39.5% of its variation (F=4.432 p=0.003).
Conclusion: In the studied population, vitamin D was inversely related to MMP-2 and leptin which are involved in coronary artery disease and acute myocardial infarction. The decrease in this hormone levels would be associated with a worse metabolic profile in acute coronary syndrome patients.
Keywords: Vitamin D, acute myocardial infarction, matrix metalloproteinases, leptin, non HDL-cholesterol, vulnerable plaque.
Current Vascular Pharmacology
Title:Vitamin D is Related to Markers of Vulnerable Plaque in Acute Myocardial Infarction
Volume: 16 Issue: 4
Author(s): Nahuel Fernandez Machulsky, Magali Barchuk, Juan Gagliardi, Diego Gonzalez, Micaela Lombardo, Alejandro Garcia Escudero, Gerardo Gigena, Federico Blanco, Laura Schreier, Bibiana Fabre and Gabriela Berg*
Affiliation:
- Universidad de Buenos Aires, Facultad de Farmacia y Bioquimica, Departamento de Bioquimica Clinica, Catedra de Bioquimica Clinica I, Buenos Aires,Argentina
Keywords: Vitamin D, acute myocardial infarction, matrix metalloproteinases, leptin, non HDL-cholesterol, vulnerable plaque.
Abstract: Background: Vitamin D is a fat soluble vitamin involved in calcium and bone metabolism; recently its deficiency has been related to cardiovascular disease. In cardiac tissue, vitamin D suppresses metalloproteinases (MMPs) expression, enzymes directly associated with vulnerable plaque.
Objective: To investigate whether the association between vitamin D and leptin is related to markers of vulnerable plaque, such as MMPs in patients with acute myocardial infarction.
Methods: We studied 66 male patients with acute myocardial infarction, undergoing primary angioplasty. Blood samples were obtained at admission and 24hs after the surgery. Leptin and vitamin D concentrations in serum and MMP-2 and -9 activities in plasma were determined.
Results: MMP-2 activity was increased in Vitamin D deficient/insufficient patients at admission (p=0.04) and 24 hs later (p=0.05). In a linear regression model, vitamin D explained 24% of the variance of MMP-2 activity (F=2.839 p=0.04). At admission, vitamin D correlated with serum leptin (r=-0.302 p=0.033), and explained 39.5% of its variation (F=4.432 p=0.003).
Conclusion: In the studied population, vitamin D was inversely related to MMP-2 and leptin which are involved in coronary artery disease and acute myocardial infarction. The decrease in this hormone levels would be associated with a worse metabolic profile in acute coronary syndrome patients.
Export Options
About this article
Cite this article as:
Machulsky Fernandez Nahuel , Barchuk Magali, Gagliardi Juan , Gonzalez Diego , Lombardo Micaela , Garcia Escudero Alejandro , Gigena Gerardo , Blanco Federico, Schreier Laura , Fabre Bibiana and Berg Gabriela *, Vitamin D is Related to Markers of Vulnerable Plaque in Acute Myocardial Infarction, Current Vascular Pharmacology 2018; 16 (4) . https://dx.doi.org/10.2174/1570161115666170609102506
DOI https://dx.doi.org/10.2174/1570161115666170609102506 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
Call for Papers in Thematic Issues
Advancements in Arterial Stiffness: Novel Therapeutic Frontiers
Arterial stiffness, a hallmark of cardiovascular disease, poses significant challenges in contemporary healthcare. This thematic issue delves into the multifaceted landscape of arterial stiffness and explores cutting-edge therapeutic interventions aimed at mitigating its adverse effects. Within these pages, readers will find a comprehensive overview of the mechanisms underlying arterial stiffness, ...read more
Ischemic Cardiovascular Diseases: Mechanisms, Diagnosis and Therapy
Ischemic cardiovascular disease includes myocardial infarction, coronary atherosclerotic heart disease, angina pectoris, etc., constitute the leading cause of patient mortality by preventing tissues from getting sufficient oxygen and nutrients. Ischemic heart disease, as a clinical condition, is characterized by myocardial ischemia, causing an imbalance between myocardial blood supply and demand, ...read more
TREATMENT OF CARDIOVASCULAR DISEASE IN CHRONIC AND END STAGE KIDNEY DISEASE
Cardiovascular disease still remains the leading cause of death in Chronic and End Stage Kidney Disease, accounting for more than half of all deaths in dialysis patients. During the past decade, research has been focused on novel therapeutic agents that might delay or even reverse cardiovascular disease and vascular calcification, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Intracellular Bioinorganic Chemistry and Cross Talk Among Different -Omics
Current Topics in Medicinal Chemistry Importance of Receptor-targeted Systems in the Battle Against Atherosclerosis
Current Pharmaceutical Design Metabolic Effects of Bile Acids in the Gut in Health and Disease
Current Medicinal Chemistry Gene Therapy for Osteoinduction
Current Gene Therapy Cardiovascular Tests: Use & Limits of Biochemical Markers - Therapeutic Measurements of ADMA Involved in Cardiovascular Disorders
Current Pharmaceutical Design The Therapeutic Implications of Renin-Angiotensin System Blockade in Diabetic Retinopathy
Current Pharmaceutical Biotechnology Apoptosis and Autoimmune Disease
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Metabolic Enzymes of Helminth Parasites: Potential as Drug Targets
Current Protein & Peptide Science Nutritional and Therapeutic Potential of Spirulina
Current Pharmaceutical Biotechnology Role of Gut Microbiota in Human Health and Diseases
Current Nutrition & Food Science Spinal Cord Injury Changes Cytokine Transport
CNS & Neurological Disorders - Drug Targets COVID-19 in People with Diabetes: Epidemiological Perspectives and Public Health Actions in the Middle East and North Africa (MENA) Region
Current Diabetes Reviews Animal Models for Studying Neointima Formation
Current Vascular Pharmacology Antioxidants in the Treatment of Diabetes
Current Diabetes Reviews Patent Selections:
Recent Patents on Biomarkers Editorial [Hot Topic: New Concepts of Angiotensin Receptor Blocker (ARB) in Atherosclerosis: ARB as a Metabolic-Improving Agent (Guest Editor: Minako Yamaoka-Tojo)]
Current Vascular Pharmacology Muscle Metabolism and Exercise Capacity in Cachexia
Current Pharmaceutical Design The Effects of Lipid-Regulating Therapy on Haemostatic Parameters
Current Pharmaceutical Design Atorvastatin Inhibited ROS Generation and Increased IL-1β And IL-6 Release by Mononuclear Cells from Diabetic Patients
Endocrine, Metabolic & Immune Disorders - Drug Targets Diabetes Gene Therapy: Potential and Challenges
Current Gene Therapy