Chronic Kidney Disease (CKD) is becoming a global health concern. The high percentage of people living with obesity and diabetes mellitus are part of the reason for the high prevalence of CKD. In the United States, the obesity epidemic disproportionally affects minority populations. In this chapter, we will review the epidemiology of obesity and diabetes and explore their link to CKD. We will also define CKD, and examine the increasing global burden of obesity, diabetes and CKD. We will discuss ethnic and gender disparities in these conditions and in the care received by minority patients. Finally, we will suggest management strategies to slow the progression to end stage renal disease particularly in vulnerable populations.