Frontiers in Inflammation

Volume: 2

Types of Head and Neck Malignancy

Author(s): Gabriela Ramírez-Arroyo*, Juan Carlos Hernaiz-Leonardo, Michelle Marvin-Huergo and Mario Sergio Dávalos-Fuentes

Pp: 28-76 (49)

DOI: 10.2174/9789811803246121020006

* (Excluding Mailing and Handling)


Head and neck cancer (HNC) is a heterogeneous group of malignant neoplasms, and its classification is a challenge. Based on the primary site, most literature comprehends five types of HNCs: laryngeal, pharyngeal, oral cavity, nasal cavity, and salivary gland cancer. More than 90% of HCNs are of epithelial origin, making squamous cell carcinoma the most common histological type. The prototypic HNC is a moderately differentiated squamous cell carcinoma associated with tobacco and alcohol consumption that affects older men more frequently. They are usually treated in a similar fashion. Currently, the human papillomavirus epidemic and a shift in tobacco consumption patterns are changing this trend. HNCs have a high rate of genetic heterogeneity, and molecular profiling has gained importance in the classification and future treatment of HNCs.

Keywords: HPV-positive, Laryngeal cancer, Molecular profile, Nasal cavity cancer, Oral cavity cancer, Pharyngeal cancer, Salivary gland cancer, Squamous cell carcinoma, Unknown primary.

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