Frontiers in Drug Design and Discovery

Volume: 11

Immunotherapy of Sepsis

Author(s): Sanam Dolati and Hassan Soleimanpour * .

Pp: 141-183 (43)

DOI: 10.2174/9789815036879122110007

* (Excluding Mailing and Handling)


Sepsis is a clinical condition that occurs due to dysregulated fundamental
host reaction to an infection, resulting in organ dysfunction. Proinflammatory
mediators are related to indications watched early in patients with sepsis. In spite of
decades of investigation, the morbidity and mortality of sepsis stay exceptionally very
high. Regardless of the recognition of numerous prospective targets in the complex
immune response pathways, no specific immunotherapeutic medicines are at present
accessible. Presently, immunosuppression in sepsis is a subject matter of strong
research amongst various pre-clinical and clinical studies. In fact, an improved
consideration of a patient’s immune status on a constant basis will plausibly allow
focused immunotherapy. This book chapter provides an overview of the epidemiology,
etiology, pathogenesis of sepsis and gives an outline of the challenges in
immunotherapy for patients suffering from sepsis.

Keywords: Immunotherapy, Inflammatory, Sepsis, Septic shock.

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