Toll-Like Receptors in Vector-borne Diseases

Dengue Virus and Toll-Like Receptors

Author(s): Jayalakshmi Krishnan * .

Pp: 40-44 (5)

DOI: 10.2174/9789815124545123010008

* (Excluding Mailing and Handling)


Dengue is one of the most important arboviral diseases recorded in the world. Dengue, a public health problem in tropical and subtropical countries, is spread by female Aedes mosquito bites. Among Aedes mosquitoes, Aedesaegypti is the primary vector and Aedesalbopictus is the less infective secondary vector [1]. Dengue hemorrhagic fever (DHF) is a severe form of the disease, that causes differential expression of the TLRs in dendritic cells (DCs). TLR3 and TLR9 in DCs of patients with early onset of dengue fever were unregulated, whereas in severe cases, poor expression of TLR3 and TLR9 is observed [2]. This kind of alteration in the TLR expression during dengue may alter the clinical manifestation of the disease. However, this can be considered for further research on therapeutics.

Keywords: Human peripheral blood mononuclear cells (PBMC), NF-kB mediated pathways.

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