Biocompatibility of Nanomedicines and Relation with Protein Corona

Pp: 296-316 (21)

* (Excluding Mailing and Handling)

Abstract

When NPs are included in a Biological environment, they associate with a large number of circulating proteins. As a result, they interact dynamically with each other. This structure, which is defined as PC, affects the physical parameters of NPs and causes positive or negative effects on them. PC composition is affected by many properties of NPs, such as size, shape, and surface charge. Therefore, various surface modifications on NPs directly affect PC formation and nature. Although many studies have been carried out to understand the formation and composition of the resulting PC structure, this area still maintains its popularity as a research topic. This review aims to briefly give an idea about the effect of proteins in metabolism on NPs designed as carrier molecules, the determination of these protein structures and the final fate of NPs after PC formation.

Keywords: Atomic force microscopy, Biocompatibility, Differential centrifugal sedimentation, Dynamic light scattering, Fluorescence correlation spectroscopy, Hard corona, Isothermal titration calorimetry, Nanomaterial shape, Nanoparticle, Nanoparticle application, Protein adsorption, Protein corona, Protein corona characterization, Protein corona dispersion, Protein corona stability, Protein corona formation, Small-angle X-ray scattering, Soft corona, Transmission electron microscopy, UV-visible spectroscopy.