Abstract
To date, cisplatin and its analogs are among the most effective chemotherapeutic agents for cancer treatment. However, high systemic toxicity and the propensity for patients to develop tumor resistance remain the main challenges in the clinical application. Therefore, the discovery and development of novel active chemotherapeutic agents are largely needed and the research of new metal-based anticancer drugs continues to be a very active international field. In this review paper we aim to give a detailed overview on our research work devoted to the design of novel dithiocarbamato complexes with different noble metals (such as palladium, platinum, copper, ruthenium and gold), which have gained considerable interest in both the development and the treatment of cancer. In particular, we summarize the results of the metal complexes achieved so far, focusing on the gold(III) compounds, that show outstanding in vitro and in vivo antitumor properties and reduced, or even no, systemic and renal toxicity, compared to the reference drug cisplatin.
Keywords: Anticancer agents, copper, dithiocarbamato complexes, metal-based drugs, gold, ruthenium, platinum, palladium.
Mini-Reviews in Medicinal Chemistry
Title:Noble metal-dithiocarbamates precious allies in the fight against cancer
Volume: 12 Issue: 12
Author(s): Eszter Márta Nagy, Luca Ronconi, Chiara Nardon and Dolores Fregona
Affiliation:
Keywords: Anticancer agents, copper, dithiocarbamato complexes, metal-based drugs, gold, ruthenium, platinum, palladium.
Abstract: To date, cisplatin and its analogs are among the most effective chemotherapeutic agents for cancer treatment. However, high systemic toxicity and the propensity for patients to develop tumor resistance remain the main challenges in the clinical application. Therefore, the discovery and development of novel active chemotherapeutic agents are largely needed and the research of new metal-based anticancer drugs continues to be a very active international field. In this review paper we aim to give a detailed overview on our research work devoted to the design of novel dithiocarbamato complexes with different noble metals (such as palladium, platinum, copper, ruthenium and gold), which have gained considerable interest in both the development and the treatment of cancer. In particular, we summarize the results of the metal complexes achieved so far, focusing on the gold(III) compounds, that show outstanding in vitro and in vivo antitumor properties and reduced, or even no, systemic and renal toxicity, compared to the reference drug cisplatin.
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Márta Nagy Eszter, Ronconi Luca, Nardon Chiara and Fregona Dolores, Noble metal-dithiocarbamates precious allies in the fight against cancer, Mini-Reviews in Medicinal Chemistry 2012; 12 (12) . https://dx.doi.org/10.2174/138955712802762004
DOI https://dx.doi.org/10.2174/138955712802762004 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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