Abstract
In this study, the simultaneous determination of verapamil hydrochloride, gliclazide and simvastatin in pharmaceuticals by chemometric approaches using UV spectrophotometry has been reported. Spectra of verapamil hydrochloride, gliclazide and simvastatin were recorded at several concentrations within their linear ranges and were used to compute the calibration mixture between wavelength range of 200 and 400 nm at an interval of 3 nm in pH 6.8 phosphate buffer containing 0.5% sodium lauryl sulphate (SLS). Partial least squares regression (PLS) and principle component regression (PCR) were used for chemometric analysis of the data. The analytical performances of these chemometric methods were characterized by relative prediction errors and recoveries (%) and were compared with each other. These two methods were successfully applied to pharmaceutical formulation, tablet, with no interference from excipients as indicated by the recovery study results. The proposed methods are simple, rapid and can be easily used as an alternative analysis tool in the quality control of drugs and formulation.
Keywords: Partial least square, principle component regression, verapamil hydrochloride, gliclazide, simvastatin, multivariate analysis.
Current Analytical Chemistry
Title:Chemometric Assisted Simultaneous Analysis of Verapamil Hydrochloride, Gliclazide and Simvastatin in Bulk Drug and Fixed Dose Combinatinos (polypill) - A Futuristic Approach
Volume: 10 Issue: 4
Author(s): Rahul Bhaskar, Radhika Bhaskar, Mahendra K. Sagar, Vipin Saini and Krishnamoorthy Bhat
Affiliation:
Keywords: Partial least square, principle component regression, verapamil hydrochloride, gliclazide, simvastatin, multivariate analysis.
Abstract: In this study, the simultaneous determination of verapamil hydrochloride, gliclazide and simvastatin in pharmaceuticals by chemometric approaches using UV spectrophotometry has been reported. Spectra of verapamil hydrochloride, gliclazide and simvastatin were recorded at several concentrations within their linear ranges and were used to compute the calibration mixture between wavelength range of 200 and 400 nm at an interval of 3 nm in pH 6.8 phosphate buffer containing 0.5% sodium lauryl sulphate (SLS). Partial least squares regression (PLS) and principle component regression (PCR) were used for chemometric analysis of the data. The analytical performances of these chemometric methods were characterized by relative prediction errors and recoveries (%) and were compared with each other. These two methods were successfully applied to pharmaceutical formulation, tablet, with no interference from excipients as indicated by the recovery study results. The proposed methods are simple, rapid and can be easily used as an alternative analysis tool in the quality control of drugs and formulation.
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Cite this article as:
Bhaskar Rahul, Bhaskar Radhika, Sagar K. Mahendra, Saini Vipin and Bhat Krishnamoorthy, Chemometric Assisted Simultaneous Analysis of Verapamil Hydrochloride, Gliclazide and Simvastatin in Bulk Drug and Fixed Dose Combinatinos (polypill) - A Futuristic Approach, Current Analytical Chemistry 2014; 10 (4) . https://dx.doi.org/10.2174/15734110113090990025
DOI https://dx.doi.org/10.2174/15734110113090990025 |
Print ISSN 1573-4110 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6727 |
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