Abstract
Nanotechnology is an emergent field with numerous applications in drug delivery, clinical medicine, nutriceuticals as well as in other fields also. In this techno, Solid lipid nanoparticles (SLN) is a part which consist solid colloidal particles ranging in size from 1 to 1000 nm and act as “magic bullet” when coupled with ligands/targeting ligands. SLN consisting of a solid-lipid promising advance delivery of lipophilic drugs and also used as an alternate for conventional carriers such as micro-emulsions, liposomes and nanoparticles based on natural/synthetic polymers. They are formulated from synthetic/natural lipids and optimize the drug delivery to provide a protection to sensitive drugs and obtain better/improve bioavailability with less toxicity (as compared to polymeric NPs) due to its biodegradable/bioacceptable nature. Moreover, Surface Modified SLNs is a new promising approach for protein loading and antigen delivery system.
Keywords: Nanotechnology, solid lipid nanoparticles (SLN), drug delivery, toxicity.
Nanoscience & Nanotechnology-Asia
Title:Solid Lipid Nanoparticles: An Innovative Nano-Vehicles for Drug Delivery
Volume: 4 Issue: 1
Author(s): Hema Chaudhary, Samita, Nitika Puri and Vikash Kumar
Affiliation:
Keywords: Nanotechnology, solid lipid nanoparticles (SLN), drug delivery, toxicity.
Abstract: Nanotechnology is an emergent field with numerous applications in drug delivery, clinical medicine, nutriceuticals as well as in other fields also. In this techno, Solid lipid nanoparticles (SLN) is a part which consist solid colloidal particles ranging in size from 1 to 1000 nm and act as “magic bullet” when coupled with ligands/targeting ligands. SLN consisting of a solid-lipid promising advance delivery of lipophilic drugs and also used as an alternate for conventional carriers such as micro-emulsions, liposomes and nanoparticles based on natural/synthetic polymers. They are formulated from synthetic/natural lipids and optimize the drug delivery to provide a protection to sensitive drugs and obtain better/improve bioavailability with less toxicity (as compared to polymeric NPs) due to its biodegradable/bioacceptable nature. Moreover, Surface Modified SLNs is a new promising approach for protein loading and antigen delivery system.
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Cite this article as:
Chaudhary Hema, Samita , Puri Nitika and Kumar Vikash, Solid Lipid Nanoparticles: An Innovative Nano-Vehicles for Drug Delivery, Nanoscience & Nanotechnology-Asia 2014; 4 (1) . https://dx.doi.org/10.2174/22106812113036660003
DOI https://dx.doi.org/10.2174/22106812113036660003 |
Print ISSN 2210-6812 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-6820 |
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