Abstract
Purpose: The objective of the present work was to develop a site specific gastro-retentive floating tablet of Troxipide for the treatment of peptic ulcer. Troxipide is a novel anti-ulcer agent having an elimination half-life of 7.4 hrs and mainly absorbed from the gastrointestinal tract.
Methods: 32 factorial design was applied. Dependant variables were swelling index, hardness and % drug release. Pluronic acid F127 and HPMC K 15M were used as rate controlled polymer. Optimized formulations were evaluated for physical characteristics, buoyancy, buoyancy lag-time, drug content, in- vitro drug release, floating behavior and in-vivo X-ray study.
Results: Formulation H5 (20% Pluronic acid F127 and 78% HPMC K 15M) showed a floating lag time 60 ±2 sec with a desired controlled release profile over a period of 10 hrs. FTIR and DSC studies confirmed no chemical interactions. In-vivo X-ray study for optimized formulations showed gastro retention for 6 hrs.
Conclusion: Results demonstrate feasibility of development of gastroretentive floating tablet of Troxipide.
Keywords: Factorial, gastro-retentive, peptic ulcer, troxipide, variables.
Current Drug Therapy
Title:Development and Optimization of Troxipide Floating Delivery for Treatment of Peptic Ulcer
Volume: 9 Issue: 2
Author(s): Swati C. Jagdale, Shraddha B. Kamble, Bhanudas S. Kuchekar and Aniruddha R. Chabukswar
Affiliation:
Keywords: Factorial, gastro-retentive, peptic ulcer, troxipide, variables.
Abstract: Purpose: The objective of the present work was to develop a site specific gastro-retentive floating tablet of Troxipide for the treatment of peptic ulcer. Troxipide is a novel anti-ulcer agent having an elimination half-life of 7.4 hrs and mainly absorbed from the gastrointestinal tract.
Methods: 32 factorial design was applied. Dependant variables were swelling index, hardness and % drug release. Pluronic acid F127 and HPMC K 15M were used as rate controlled polymer. Optimized formulations were evaluated for physical characteristics, buoyancy, buoyancy lag-time, drug content, in- vitro drug release, floating behavior and in-vivo X-ray study.
Results: Formulation H5 (20% Pluronic acid F127 and 78% HPMC K 15M) showed a floating lag time 60 ±2 sec with a desired controlled release profile over a period of 10 hrs. FTIR and DSC studies confirmed no chemical interactions. In-vivo X-ray study for optimized formulations showed gastro retention for 6 hrs.
Conclusion: Results demonstrate feasibility of development of gastroretentive floating tablet of Troxipide.
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Cite this article as:
Jagdale C. Swati, B. Kamble Shraddha, S. Kuchekar Bhanudas and R. Chabukswar Aniruddha, Development and Optimization of Troxipide Floating Delivery for Treatment of Peptic Ulcer, Current Drug Therapy 2014; 9 (2) . https://dx.doi.org/10.2174/1574885508666131217003926
DOI https://dx.doi.org/10.2174/1574885508666131217003926 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
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