Abstract
The recent emergence of anticancer activity of thiourea derivatives have inspired the medicinal chemist to design and synthesize new thiourea derivatives. These thiourea based anticancer chemotherapeutics inhibit cancer propagation by acting as inhibitors of topoisomerase, protein tyrosine kinase, somatostatin agonists, sirtuins, and carbonic anhydrase (CA). This review summarizes the recent developments on the thiourea based anticancer chemotherapeutics.
Keywords: Anticancer chemotherapeutics, carbonic anhydrase (CA) inhibitors, protein tyrosine kinase inhibitors, sirtuins inhibitors, thiourea, somatostatin agonists, topoisomerase inhibitors.
Anti-Cancer Agents in Medicinal Chemistry
Title:Recent Developments on Thiourea Based Anticancer Chemotherapeutics
Volume: 15 Issue: 2
Author(s): Vikas Kumar and Swapandeep Singh Chimni
Affiliation:
Keywords: Anticancer chemotherapeutics, carbonic anhydrase (CA) inhibitors, protein tyrosine kinase inhibitors, sirtuins inhibitors, thiourea, somatostatin agonists, topoisomerase inhibitors.
Abstract: The recent emergence of anticancer activity of thiourea derivatives have inspired the medicinal chemist to design and synthesize new thiourea derivatives. These thiourea based anticancer chemotherapeutics inhibit cancer propagation by acting as inhibitors of topoisomerase, protein tyrosine kinase, somatostatin agonists, sirtuins, and carbonic anhydrase (CA). This review summarizes the recent developments on the thiourea based anticancer chemotherapeutics.
Export Options
About this article
Cite this article as:
Kumar Vikas and Chimni Singh Swapandeep, Recent Developments on Thiourea Based Anticancer Chemotherapeutics, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (2) . https://dx.doi.org/10.2174/1871520614666140407123526
DOI https://dx.doi.org/10.2174/1871520614666140407123526 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Bitter Gourd (Momordica charantia) is a Cornucopia of Health: A Review of its Credited Antidiabetic, Anti-HIV, and Antitumor Properties
Current Molecular Medicine Targeting Hsp90 in Non-Cancerous Maladies
Current Topics in Medicinal Chemistry Thalidomide Analogues as Anticancer Drugs
Recent Patents on Anti-Cancer Drug Discovery CETUXIMAB: From Bench to Bedside
Current Cancer Drug Targets Potential Anti-cancer Drugs Commonly Used for Other Indications
Current Cancer Drug Targets Development of Method for Three-Point Data Estimation and SVR-QSAR Model to Screen Anti Cancer Leads
Combinatorial Chemistry & High Throughput Screening Novel Insights Into the Role of MicroRNA in Lung Cancer Resistance to Treatment and Targeted Therapy
Current Cancer Drug Targets Combining Oncolytic Virotherapy and Cytotoxic Therapies to Fight Cancer
Current Pharmaceutical Design Viral Vectors for Cancer Gene Therapy: Viral Dissemination and Tumor Targeting
Current Gene Therapy Synthesis, Antitumor Activity and Molecular Docking Studies on Seven Novel Thiazacridine Derivatives
Combinatorial Chemistry & High Throughput Screening CXCL12-CXCR4 Axis in Angiogenesis, Metastasis and Stem Cell Mobilization
Current Pharmaceutical Design A Review on the Effects of Androgen Deprivation Therapy (ADT) on Bone Health Status in Men with Prostate Cancer
Endocrine, Metabolic & Immune Disorders - Drug Targets Meet Our Editorial Board Member:
Current Cancer Therapy Reviews Alternative Medicine Safety: Agaricus blazei and Propolis
Combinatorial Chemistry & High Throughput Screening Principles and Therapeutic Relevance for Targeting Mitochondria in Aging and Neurodegenerative Diseases
Current Pharmaceutical Design Oncolytic Viruses: The Best is Yet to Come
Current Cancer Drug Targets ATP Citrate Lyase (ACLY): A Promising Target for Cancer Prevention and Treatment
Current Drug Targets Effects of Hyperlipidemia and Cardiovascular Diseases on Proliferation, Differentiation and Homing of Mesenchymal Stem Cells
Current Stem Cell Research & Therapy Histone Variant H2A.Z Can Serve as a New Target for Breast Cancer Therapy
Current Medicinal Chemistry Eliminating Ovarian Cancer Stem Cells: A Potential Therapeutic Target for Ovarian Cancer Chemoresistance
Current Protein & Peptide Science