Abstract
Protein kinases (PKs) mediate the reversible conversion of substrate proteins to phosphorylated forms, a key process in controlling intracellular signaling transduction cascades. Pluripotency is, among others, characterized by specifically expressed PKs forming a highly interconnected regulatory network that culminates in a finely-balanced molecular switch. Current high-throughput phosphoproteomic approaches have shed light on the specific regulatory PKs and their function in controlling pluripotent states. Pluripotent cell-derived endothelial and hematopoietic developments represent an example of the importance of pluripotency in cancer therapeutics and organ regeneration. This review attempts to provide the hitherto known kinome profile and the individual characterization of PK-related pathways that regulate pluripotency. Elucidating the underlying intrinsic and extrinsic signals may improve our understanding of the different pluripotent states, the maintenance or induction of pluripotency, and the ability to tailor lineage differentiation, with a particular focus on endothelial cell differentiation for anti-cancer treatment, cell-based tissue engineering, and regenerative medicine strategies.
Keywords: Endothelial cells, phosphorylation, pluripotency, protein kinases, signaling pathways, stem cell.
Current Stem Cell Research & Therapy
Title:Protein Kinases and Associated Pathways in Pluripotent State and Lineage Differentiation
Volume: 9 Issue: 5
Author(s): Melina Shoni, Kathy O. Lui, Demetrios G. Vavvas, Michael G. Muto, Ross S. Berkowitz, Nikolaos Vlahos and Shu-Wing Ng
Affiliation:
Keywords: Endothelial cells, phosphorylation, pluripotency, protein kinases, signaling pathways, stem cell.
Abstract: Protein kinases (PKs) mediate the reversible conversion of substrate proteins to phosphorylated forms, a key process in controlling intracellular signaling transduction cascades. Pluripotency is, among others, characterized by specifically expressed PKs forming a highly interconnected regulatory network that culminates in a finely-balanced molecular switch. Current high-throughput phosphoproteomic approaches have shed light on the specific regulatory PKs and their function in controlling pluripotent states. Pluripotent cell-derived endothelial and hematopoietic developments represent an example of the importance of pluripotency in cancer therapeutics and organ regeneration. This review attempts to provide the hitherto known kinome profile and the individual characterization of PK-related pathways that regulate pluripotency. Elucidating the underlying intrinsic and extrinsic signals may improve our understanding of the different pluripotent states, the maintenance or induction of pluripotency, and the ability to tailor lineage differentiation, with a particular focus on endothelial cell differentiation for anti-cancer treatment, cell-based tissue engineering, and regenerative medicine strategies.
Export Options
About this article
Cite this article as:
Shoni Melina, Lui O. Kathy, Vavvas G. Demetrios, Muto G. Michael, Berkowitz S. Ross, Vlahos Nikolaos and Ng Shu-Wing, Protein Kinases and Associated Pathways in Pluripotent State and Lineage Differentiation, Current Stem Cell Research & Therapy 2014; 9 (5) . https://dx.doi.org/10.2174/1574888X09666140616130217
DOI https://dx.doi.org/10.2174/1574888X09666140616130217 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Increased Radioisotope Accumulation Around Pulmonary Arteriovenous Fistula Illustrated by Tc-99m-macroaggregated Albumin Scintigraphy and SPECT/CT in a Patient with Osler-Weber-Rendu Syndrome
Current Medical Imaging Matrix Metalloproteinases: New Routes to the Use of MT1-MMP As A Therapeutic Target in Angiogenesis-Related Disease
Current Pharmaceutical Design Neuropilin Signalling in Vascular Development and Pathology
Current Angiogenesis (Discontinued) Gene Clusters, Molecular Evolution and Disease: A Speculation
Current Genomics New Therapeutic Strategies in Perinatal Stroke
Current Drug Targets - CNS & Neurological Disorders Diagnosis and Prognosis of Fetal Cardiomyopathies: A Review
Current Pharmaceutical Design Epigenetic Effects of Cadmium in Cancer: Focus on Melanoma
Current Genomics Approach in Management of Aplasia Cutis Congenita in a Newborn with Adam Oliver Syndrome
New Emirates Medical Journal Editorial [Hot Topic: New Avenues of Research on Multiple Sclerosis from the Perspective of Chronic Cerebrospinal Venous Insufficiency Paradigm (Guest Editor: Marian Simka)]
Reviews on Recent Clinical Trials Tumour-Specific Uptake of Anti-Cancer Drugs: The Future is Here
Current Drug Metabolism The Finely Regulating Well-defined Functional Polymeric Nanocarriers for Anti-tumor Immunotherapy
Mini-Reviews in Medicinal Chemistry Estrogenic Compounds, Estrogen Receptors and Vascular Cell Signaling in the Aging Blood Vessels
Current Medicinal Chemistry A Role for TGF-β Signaling in Neurodegeneration: Evidence from Genetically Engineered Models
Current Alzheimer Research Relationship Between Body Mass Index and Reproduction
Current Women`s Health Reviews Cholesterol Homeostasis Failure in the Brain: Implications for Synaptic Dysfunction and Cognitive Decline
Current Medicinal Chemistry Filling the Gaps between the In Vivo and In Vitro Microenvironment: Engineering of Spheroids for Stem Cell Technology
Current Stem Cell Research & Therapy Matrix Metalloproteinases as Potential Targets in the Venous Dilation Associated with Varicose Veins
Current Drug Targets Novel Concepts in the Pathogenesis and Management of Pediatric Hypertension
Current Pediatric Reviews Valve Endothelial Cells – Not Just Any Old Endothelial Cells
Current Vascular Pharmacology Diabetes and the Impairment of Reproductive Function: Possible Role of Mitochondria and Reactive Oxygen Species
Current Diabetes Reviews