Abstract
Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. Most AAAs are asymptomatic and screening programs have been introduced to identify AAAs at an early stage in some countries. There is currently no accepted therapy for early stage or small AAAs, which are frequently identified by such programs. In this review, we discuss work underway to identify targets for medical treatments to limit progression of small AAAs. Specifically we discuss studies, which have examined the potential of targeting inflammation, proteolysis, the renin-angiotensin system, the coagulation system and sex hormones as approaches to limiting AAA pathogenesis. As yet, none of the treatment targets have translated into an agent, which can effectively reduce AAA progression in clinical practice.
Keywords: Abdominal aortic aneurysm, animal models, clinical trial, pharmacotherapy.
Current Drug Targets
Title:Targets for Medical Therapy to Limit Abdominal Aortic Aneurysm Progression
Volume: 15 Issue: 9
Author(s): Theophilus I. Emeto, Sai-Wang Seto and Jonathan Golledge
Affiliation:
Keywords: Abdominal aortic aneurysm, animal models, clinical trial, pharmacotherapy.
Abstract: Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. Most AAAs are asymptomatic and screening programs have been introduced to identify AAAs at an early stage in some countries. There is currently no accepted therapy for early stage or small AAAs, which are frequently identified by such programs. In this review, we discuss work underway to identify targets for medical treatments to limit progression of small AAAs. Specifically we discuss studies, which have examined the potential of targeting inflammation, proteolysis, the renin-angiotensin system, the coagulation system and sex hormones as approaches to limiting AAA pathogenesis. As yet, none of the treatment targets have translated into an agent, which can effectively reduce AAA progression in clinical practice.
Export Options
About this article
Cite this article as:
Emeto I. Theophilus, Seto Sai-Wang and Golledge Jonathan, Targets for Medical Therapy to Limit Abdominal Aortic Aneurysm Progression, Current Drug Targets 2014; 15 (9) . https://dx.doi.org/10.2174/1389450115666140804155036
DOI https://dx.doi.org/10.2174/1389450115666140804155036 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Doxycycline Inhibition of Abdominal Aortic Aneurysm Growth - A Systematic Review of the Literature
Current Vascular Pharmacology Surgical Ventricular Restoration: An Operation To Reverse Remodeling - The Basic Science (Part I)
Current Cardiology Reviews Therapeutic Angiogenesis in Ischemic Tissues by Growth Factors and Bone Marrow Mononuclear Cells Administration: Biological Foundation and Clinical Prospects
Current Stem Cell Research & Therapy IgG4-Related Disease (IgG4+MOLPS) – Diagnostic Criteria and Diagnostic Problems
Current Immunology Reviews (Discontinued) The Tree of Sirtuins and the Garden of Cardiovascular Youth
Current Vascular Pharmacology Effect of Immunoglobulin Therapy on Blood Viscosity and potential concerns of Thromboembolism, Especially in Patients with Acute Kawasaki Disease
Recent Patents on Cardiovascular Drug Discovery Gauzoma in A Scleroderma Patient Following Open Heart Surgery: A Case Report
Current Rheumatology Reviews Recent Patents on Biomedical Devices and Nanomaterials for Hyperthermal Therapy of Cancer
Recent Patents on Nanomedicine The Genetic Basis of Kidney Cancer: Why is Tuberous Sclerosis Complex Often Overlooked?
Current Molecular Medicine Multimodality Imaging in Acute Ischemic Stroke
Current Medical Imaging Genetics of Atherosclerosis in Murine Models
Current Drug Targets Colloid Update
Current Pharmaceutical Design Intravenous Immunoglobulin Therapy in Dermatologic Disorders
Inflammation & Allergy - Drug Targets (Discontinued) Clinical Pharmacology of Non-Steroidal Anti-Inflammatory Drugs: A Review
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry A Review of Pediatric Mediastinal Masses and Castlemans Disease
Current Pediatric Reviews The Role of microRNA in Ischemic and Hemorrhagic Stroke
Current Drug Delivery Virus-Associated Vasculitides: An Update
Current Immunology Reviews (Discontinued) Porphyrin-Photosensitized Processes: Their Applications in the Prevention of Arterial Restenosis
Cardiovascular & Hematological Agents in Medicinal Chemistry The Role of Serum Calprotectin as a New Marker in Abdominal Aortic Aneurysms – A Preliminary Report
Current Pharmaceutical Biotechnology Early Brain Injury or Vasospasm? An Overview of Common Mechanisms
Current Drug Targets