Abstract
Recently, the development of nanotechnology and nanomaterial has promoted extremely the application of drug delivery systems in the biomedical field. However, the drug delivery into the central nervous system (CNS) is limited because the existence of the blood brain barrier (BBB). Therefore, to develop the efficient drug delivery systems (DDS) for crossing the BBB into the lesions is necessary. The holistic DDS, which successfully transfer drug into the brain, should be explored on the basis of biodegradable and non-cytotoxic nanomaterial. In this review, we discussed the applications of nanoparticles-mediated DDS in the CNS and focused on the varied nanocarrier strategies used for crossing the BBB and targeting the brain lesions, such as poly (PEG, PLA, and PLGA) covalent-attached to nanoparticles strategies, lipid nanocarrier DDS strategy, polymeric/dendritic nanocarrier DDS strategies, magnetic nanocarrier DDS strategy, and other (carbon nanotubes, viral, gold, silica etc.) nanocarrier DDS strategies. In conclusion, the platform carrying nanoparticles-based drug vehicle is vital and promising for developing the special brain drug delivery system. In future multifunctional nanocarriers may play more important role in treating various neurological diseases.
Keywords: Nanoparticle, drug delivery system, central nervous system, blood brain barrier.
Current Organic Chemistry
Title:Nanoparticle-mediated Drug Delivery Systems (DDS) in the Central Nervous System
Volume: 21 Issue: 3
Author(s): Guilong Zhang, Lukui Chen, Xiaoyuan Guo, Ahsan A. Khan, Yuchun Gu and Ning Gu
Affiliation:
Keywords: Nanoparticle, drug delivery system, central nervous system, blood brain barrier.
Abstract: Recently, the development of nanotechnology and nanomaterial has promoted extremely the application of drug delivery systems in the biomedical field. However, the drug delivery into the central nervous system (CNS) is limited because the existence of the blood brain barrier (BBB). Therefore, to develop the efficient drug delivery systems (DDS) for crossing the BBB into the lesions is necessary. The holistic DDS, which successfully transfer drug into the brain, should be explored on the basis of biodegradable and non-cytotoxic nanomaterial. In this review, we discussed the applications of nanoparticles-mediated DDS in the CNS and focused on the varied nanocarrier strategies used for crossing the BBB and targeting the brain lesions, such as poly (PEG, PLA, and PLGA) covalent-attached to nanoparticles strategies, lipid nanocarrier DDS strategy, polymeric/dendritic nanocarrier DDS strategies, magnetic nanocarrier DDS strategy, and other (carbon nanotubes, viral, gold, silica etc.) nanocarrier DDS strategies. In conclusion, the platform carrying nanoparticles-based drug vehicle is vital and promising for developing the special brain drug delivery system. In future multifunctional nanocarriers may play more important role in treating various neurological diseases.
Export Options
About this article
Cite this article as:
Zhang Guilong, Chen Lukui, Guo Xiaoyuan, Khan A. Ahsan, Gu Yuchun and Gu Ning, Nanoparticle-mediated Drug Delivery Systems (DDS) in the Central Nervous System, Current Organic Chemistry 2017; 21 (3) . https://dx.doi.org/10.2174/1385272820666161017170325
DOI https://dx.doi.org/10.2174/1385272820666161017170325 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Convection Enhanced Delivery of Macromolecules for Brain Tumors
Current Drug Discovery Technologies Boron Nitride Nanotubes: Production, Properties, Biological Interactions and Potential Applications as Therapeutic Agents in Brain Diseases
Current Nanoscience Proteomics Approach to Illustrate Drug Action Mechanisms
Current Drug Discovery Technologies Tyrosine Kinases as Molecular Targets to Inhibit Cancer Progression and Metastasis
Current Pharmaceutical Design Histone Deacetylase Inhibition: A Differentiation Therapy for Cultured Primary Hepatocytes?
Current Enzyme Inhibition Geniposide Attenuates Mitochondrial Dysfunction and Memory Deficits in APP/PS1 Transgenic Mice
Current Alzheimer Research Synthetic and Biological Aspects of Thiadiazoles and their Condensed Derivatives: An Overview
Current Topics in Medicinal Chemistry Monofunctional Platinum (PtII) Compounds – Shifting the Paradigm in Designing New Pt-based Anticancer Agents
Current Medicinal Chemistry Effect of DNA Repair Deficiencies on the Cytotoxicity of Drugs Used in Cancer Therapy - A Review
Current Medicinal Chemistry Histone Deacetylase Inhibitors: Molecular and Biological Activity as a Premise to Clinical Application
Current Drug Metabolism The Relationship Between Lithium and Cancer Proliferation: A Case-Based Review of the Literature
Current Drug Metabolism Novel Patents and Cancer Therapies for Transforming Growth Factor- Beta and Urokinase Type Plasminogen Activator: Potential Use of Their Interplay in Tumorigenesis
Recent Patents on Anti-Cancer Drug Discovery Meet Our Editorial Board Member
Current Pharmacogenomics and Personalized Medicine Passive Targeting of Cyclophosphamide-Loaded Carbonate Apatite Nanoparticles to Liver Impedes Breast Tumor Growth in a Syngeneic Model
Current Pharmaceutical Design Exercise-Induced Overexpression of Angiogenic Factors and Reduction of Ischemia / Reperfusion Injury in Stroke
Current Neurovascular Research Recent Patents on Mesenchymal Stem Cell Mediated Therapy in Inflammatory Diseases
Recent Patents on Inflammation & Allergy Drug Discovery Subject Index to Volume 4
Current Genomics Peptide-Receptor Ligands and Multivalent Approach
Anti-Cancer Agents in Medicinal Chemistry Role of Unani Medicines in Cancer Control and Management
Current Drug Therapy Mitochondrial Dysfunction in Gliomas: Pharmacotherapeutic Potential of Natural Compounds
Current Neuropharmacology