Abstract
Background: This is a short review on the most recent studies on curcumin and its analogs, including the studies from the laboratories of authors. The diverse medicinal properties of curcumin itself reported in the recent years are reviewed. Although curcumin has shown great potential in treating various diseases, it has not been approved as a clinical drug candidate because of its poor pharmacokinetics.
Method: The recent methods developed to solve this problem are briefly described. Conclusion: The biological and other properties of synthetic curcumin analogs (diarylheptanoids and diarylpentanoid monocarbonyl derivatives) reported in the recent literature are also presented.Keywords: Anticancer, antioxidant, curcumin analogs, curcumin, diarylheptanoids, diarylpentanoids, formulations, mechanism of action, Michael acceptor, pharmacokinetics, topoisomerase IIα inhibitors.
Mini-Reviews in Medicinal Chemistry
Title:Curcumin: Not So Spicy After All
Volume: 17 Issue: 15
Author(s): Amitabh Jha*, Prabhu. P. Mohapatra, Salma A. AlHarbi and Nusrat Jahan
Affiliation:
- Department of Chemistry, Acadia University, Wolfville, NS B4P 2R6,Canada
Keywords: Anticancer, antioxidant, curcumin analogs, curcumin, diarylheptanoids, diarylpentanoids, formulations, mechanism of action, Michael acceptor, pharmacokinetics, topoisomerase IIα inhibitors.
Abstract: Background: This is a short review on the most recent studies on curcumin and its analogs, including the studies from the laboratories of authors. The diverse medicinal properties of curcumin itself reported in the recent years are reviewed. Although curcumin has shown great potential in treating various diseases, it has not been approved as a clinical drug candidate because of its poor pharmacokinetics.
Method: The recent methods developed to solve this problem are briefly described. Conclusion: The biological and other properties of synthetic curcumin analogs (diarylheptanoids and diarylpentanoid monocarbonyl derivatives) reported in the recent literature are also presented.Export Options
About this article
Cite this article as:
Jha Amitabh*, Mohapatra P. Prabhu., AlHarbi A. Salma and Jahan Nusrat, Curcumin: Not So Spicy After All, Mini-Reviews in Medicinal Chemistry 2017; 17 (15) . https://dx.doi.org/10.2174/1389557517666170228114234
DOI https://dx.doi.org/10.2174/1389557517666170228114234 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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