Abstract
Novel discoveries in medicine have provided understanding of the mechanisms involved in the development and maintenance of pathologies, thereby leading to the identification of new therapeutic targets and consequently new drugs. Thalidomide, independently of its teratogenic effects, is one drug able to regulate the immune system. Deeper studies about thalidomide have started on the 90s, when some of its action mechanisms were elucidated. Following the initial description of high systemic TNF-α production in patients with erythema nodosum leprosum (ENL), and the reduction of TNF-α caused by the administration of thalidomide in these patients, the drug was shown to present multiple effects, making it difficult to understand the mechanism of its successful use in some pathologies. Such studies have extended the rational application of thalidomide to various disorders in which the participation of one or more factors modulated by the drug has been related. In this review, we describe some of the mechanisms of action of thalidomide, its collateral effects, and some of its pharmacodynamical properties. We also discuss the applications of the drug in various diseases, and especially in leprosy and multiple myeloma, on the basis of an extensive review of the literature.
Keywords: CYP2C19, inflammatory disorders, Cyclooxigenase-2, angiogenesis, immunomodulatory, untreated reactional patients (ENL)
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Thalidomide: An Overview of its Pharmacological Mechanisms of Action
Volume: 5 Issue: 1
Author(s): Elizabeth P. Sampaio, Daniel S. Carvalho, Jose A. C. Nery, Ulisses G. Lopes and Euzenir N. Sarno
Affiliation:
Keywords: CYP2C19, inflammatory disorders, Cyclooxigenase-2, angiogenesis, immunomodulatory, untreated reactional patients (ENL)
Abstract: Novel discoveries in medicine have provided understanding of the mechanisms involved in the development and maintenance of pathologies, thereby leading to the identification of new therapeutic targets and consequently new drugs. Thalidomide, independently of its teratogenic effects, is one drug able to regulate the immune system. Deeper studies about thalidomide have started on the 90s, when some of its action mechanisms were elucidated. Following the initial description of high systemic TNF-α production in patients with erythema nodosum leprosum (ENL), and the reduction of TNF-α caused by the administration of thalidomide in these patients, the drug was shown to present multiple effects, making it difficult to understand the mechanism of its successful use in some pathologies. Such studies have extended the rational application of thalidomide to various disorders in which the participation of one or more factors modulated by the drug has been related. In this review, we describe some of the mechanisms of action of thalidomide, its collateral effects, and some of its pharmacodynamical properties. We also discuss the applications of the drug in various diseases, and especially in leprosy and multiple myeloma, on the basis of an extensive review of the literature.
Export Options
About this article
Cite this article as:
Sampaio P. Elizabeth, Carvalho S. Daniel, Nery A. C. Jose, Lopes G. Ulisses and Sarno N. Euzenir, Thalidomide: An Overview of its Pharmacological Mechanisms of Action, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2006; 5 (1) . https://dx.doi.org/10.2174/187152306775537337
DOI https://dx.doi.org/10.2174/187152306775537337 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Oxidative Stress and Mitochondrial Dysfunction in Type 2 Diabetes
Current Pharmaceutical Design Network Pharmacology Analysis of Molecular Mechanism of Curcuma longa L. Extracts Regulating Glioma Immune Inflammatory Factors: Implications for Precise Cancer Treatment
Current Topics in Medicinal Chemistry Dexamethasone Reduces Cell Adhesion and Migration of T47D Breast Cancer Cell Line
Anti-Cancer Agents in Medicinal Chemistry The TWEAK-Fn14 System: Breaking the Silence of Cytokine-Induced Skeletal Muscle Wasting
Current Molecular Medicine Comparison Between 18F-Dopa and 18F-Fet PET/CT in Patients with Suspicious Recurrent High Grade Glioma: A Literature Review and Our Experience
Current Radiopharmaceuticals Microarrays and the Genetic Analysis of Brain Tumors
Current Genomics Predicting Targeted Polypharmacology for Drug Repositioning and Multi- Target Drug Discovery
Current Medicinal Chemistry Cannabinoid Receptors as Therapeutic Targets
Current Pharmaceutical Design Cell Cycle Inhibition in Malignant Lymphoma: Disease Control by Attacking the Cellular Proliferation Machinery
Current Drug Targets Circulating microRNAs in Hepatocellular Carcinoma: Potential Diagnostic and Prognostic Biomarkers
Current Pharmaceutical Design Transporters at CNS Barrier Sites: Obstacles or Opportunities for Drug Delivery?
Current Pharmaceutical Design Genetic Modification of Natural Killer Cells for Leukemia Therapies
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2-(ω-Carboxyethyl)pyrrole Antibody as a New Inhibitor of Tumor Angiogenesis and Growth
Anti-Cancer Agents in Medicinal Chemistry Novel Oncogenic Protein Kinase Inhibitors for Cancer Therapy
Current Medicinal Chemistry - Anti-Cancer Agents 9th International Meeting on Metabotropic Gglutamate Receptors (Taormina, Sicily, October 1-6, 2017).
Current Neuropharmacology Dietary Prevention of Cancer: Anticancer and Antiangiogenic Properties of Green Tea Polyphenols
Medicinal Chemistry Reviews - Online (Discontinued) PRL-3, An Emerging Marker of Carcinogenesis, Is Strongly Associated with Poor Prognosis
Anti-Cancer Agents in Medicinal Chemistry Exploring the Nucleolar Proteome: Novel Concepts for Chaperone Trafficking and Function
Current Proteomics Applications of Important Polysaccharides in Drug Delivery
Current Pharmaceutical Design Radiolabeled RGD Peptides as Integrin alpha(v)beta3–targeted PET Tracers
Current Medicinal Chemistry