Abstract
Diabetes mellitus type 2 is a metabolic disease associated with chronic hyperglycaemia, which leads to a wide range of complications, including microvascular and macrovascular alterations, retinopathy, nephropathy and renal disease or peripheral neuropathy. Several intracellular pathways have been shown to be associated to type 2 diabetes mellitus, ranging from an altered insulin receptor-associated signalling to an abnormal intracellular calcium homeostasis or disturbances in Na+ handling. A number of diabetes-associated complications have been reported to be associated with hyperactivity of certain protein tyrosine kinases, such as those cytosolic kinases of the Src family, involved in the altered intracellular calcium mobilisation and platelet-derived cardiovascular problems and in glomerular injury, or the JAK family of tyrosine kinases involved in hyperglycaemia-induced renal failure. There has been a considerable effort in several laboratories to identify suitable targets for the design of drugs against this disease. The development of tyrosine kinase inhibitors suitable for medical purposes might represent a significant advance in the therapy of complications associated to type 2 diabetes mellitus.
Keywords: Type 2 diabetes mellitus, calcium homeostasis, tyrosine kinases
Current Enzyme Inhibition
Title: Roles of Calcium and Tyrosine Kinases in the Pathogenesis of Type 2 Diabetes Mellitus
Volume: 2 Issue: 1
Author(s): J. A. Rosado, P. C. Redondo, J. A. Pariente and G. M. Salido
Affiliation:
Keywords: Type 2 diabetes mellitus, calcium homeostasis, tyrosine kinases
Abstract: Diabetes mellitus type 2 is a metabolic disease associated with chronic hyperglycaemia, which leads to a wide range of complications, including microvascular and macrovascular alterations, retinopathy, nephropathy and renal disease or peripheral neuropathy. Several intracellular pathways have been shown to be associated to type 2 diabetes mellitus, ranging from an altered insulin receptor-associated signalling to an abnormal intracellular calcium homeostasis or disturbances in Na+ handling. A number of diabetes-associated complications have been reported to be associated with hyperactivity of certain protein tyrosine kinases, such as those cytosolic kinases of the Src family, involved in the altered intracellular calcium mobilisation and platelet-derived cardiovascular problems and in glomerular injury, or the JAK family of tyrosine kinases involved in hyperglycaemia-induced renal failure. There has been a considerable effort in several laboratories to identify suitable targets for the design of drugs against this disease. The development of tyrosine kinase inhibitors suitable for medical purposes might represent a significant advance in the therapy of complications associated to type 2 diabetes mellitus.
Export Options
About this article
Cite this article as:
Rosado A. J., Redondo C. P., Pariente A. J. and Salido M. G., Roles of Calcium and Tyrosine Kinases in the Pathogenesis of Type 2 Diabetes Mellitus, Current Enzyme Inhibition 2006; 2 (1) . https://dx.doi.org/10.2174/157340806775473553
DOI https://dx.doi.org/10.2174/157340806775473553 |
Print ISSN 1573-4080 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6662 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Flavonoids in Atherosclerosis: An Overview of Their Mechanisms of Action
Current Medicinal Chemistry Extrahepatic Targets and Cellular Reactivity of Drug Metabolites
Current Medicinal Chemistry New Insight into the Mechanisms of <i>Ginkgo Biloba</i> Extract in Vascular Aging Prevention
Current Vascular Pharmacology Platelet and Soluble Glycoprotein VI - Novel Applications in Diagnosis and Therapy
Current Drug Targets A Scientometrics Analysis and Visualization of Depressive Disorder
Current Neuropharmacology Sleep Apnea and Coronary Heart Disease: From Dusk Till Dawn and Further
Current Respiratory Medicine Reviews Aldose Reductase, Oxidative Stress and Diabetic Cardiovascular Complications
Cardiovascular & Hematological Agents in Medicinal Chemistry Functional Food: Product Development and Health Benefits
Recent Patents on Engineering Key Relevance of Epigenetic Programming of Adiponectin Gene in Pathogenesis of Metabolic Disorders
Endocrine, Metabolic & Immune Disorders - Drug Targets A Systematic Review on Pharmaceutical Diabetic Care Services in the United Arab Emirates (UAE)
Current Diabetes Reviews Current Problems, New Opportunities and Future Directions of Antiplatelet Therapy - Increasing Role of Novel Antiplatelet Agents in Cardiovascular Diseases
Recent Patents on Cardiovascular Drug Discovery Heart Disease in Patients with HIV/AIDS-An Emerging Clinical Problem
Current Cardiology Reviews Peptides, Proteins and Peptide/Protein-Polymer Conjugates as Drug Delivery System
Protein & Peptide Letters MiR-106a Associated with Diabetic Peripheral Neuropathy Through the Regulation of 12/15-LOX-meidiated Oxidative/Nitrative Stress
Current Neurovascular Research Metformin and Energy Metabolism in Breast Cancer: From Insulin Physiology to Tumour-initiating Stem Cells
Current Molecular Medicine Modulation of Cardiovascular Remodeling with Statins: Fact or Fiction?
Current Vascular Pharmacology The Role of Combined Assessment of Defense Against Oxidative Stress and Inflammation in the Evaluation of Peripheral Arterial Disease
Current Molecular Medicine Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer’s Disease
Current Neurovascular Research Indications for Surgery and Operative Techniques in Infective Endocarditis in the Present Day
Infectious Disorders - Drug Targets Fitness or Fatness: The Debate Continues for AMP-Activated Protein Kinase in Heart Function
Current Cardiology Reviews