Abstract
The full development of allergic airway responses in asthma is critically dependent on CD4+ T cells. Through interaction with CD4 molecule, IL-16 acts specifically on CD4+ cells. In vitro, IL-16 has been characterized as a chemoattractant for CD4+ immune cells and as a regulator of T cell functions inhibiting T cell receptor-mediated activation, an effect that is more predominant in T 2 cells. IL-16/CD4 interaction also regulates chemokine receptor signaling. The contribution of IL-16 in allergic airway inflammation has been studied both in humans and in animal models of asthma. Airway expression of IL-16 is upregulated in patients with ongoing asthma and in experimental models of allergic airway inflammation. The immunomodulatory function of IL-16 has been demonstrated in murine models of asthma in which systemic treatment with IL-16 inhibits antigen-induced airway responses and T 2 T cell cytokine production. This review addresses the current data regarding IL-16 protein and gene structure; the interaction of IL-16 with CD4; the biological activities of IL-16; its immunoregulatory role in allergic airway inflammation. In addition, we discuss the known and potential therapeutic applications for IL-16 and IL-16 peptide derivatives in allergic airway inflammation.
Keywords: T cells, immune regulation, asthma, allergy
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Derivatives of IL-16 to Modulate Airway Inflammation
Volume: 7 Issue: 4
Author(s): Sophie Laberge and William W. Cruikshank
Affiliation:
Keywords: T cells, immune regulation, asthma, allergy
Abstract: The full development of allergic airway responses in asthma is critically dependent on CD4+ T cells. Through interaction with CD4 molecule, IL-16 acts specifically on CD4+ cells. In vitro, IL-16 has been characterized as a chemoattractant for CD4+ immune cells and as a regulator of T cell functions inhibiting T cell receptor-mediated activation, an effect that is more predominant in T 2 cells. IL-16/CD4 interaction also regulates chemokine receptor signaling. The contribution of IL-16 in allergic airway inflammation has been studied both in humans and in animal models of asthma. Airway expression of IL-16 is upregulated in patients with ongoing asthma and in experimental models of allergic airway inflammation. The immunomodulatory function of IL-16 has been demonstrated in murine models of asthma in which systemic treatment with IL-16 inhibits antigen-induced airway responses and T 2 T cell cytokine production. This review addresses the current data regarding IL-16 protein and gene structure; the interaction of IL-16 with CD4; the biological activities of IL-16; its immunoregulatory role in allergic airway inflammation. In addition, we discuss the known and potential therapeutic applications for IL-16 and IL-16 peptide derivatives in allergic airway inflammation.
Export Options
About this article
Cite this article as:
Laberge Sophie and Cruikshank W. William, Derivatives of IL-16 to Modulate Airway Inflammation, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2008; 7 (4) . https://dx.doi.org/10.2174/187152308786847825
DOI https://dx.doi.org/10.2174/187152308786847825 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Propitious Profile of Peppery Piperine
Current Molecular Pharmacology Impact on Pharmaceutical Industry due to Sudden Pandemic Attack (COVID-19)
Coronaviruses Microvascular Theory of Exercise-Induced Bronchoconstriction in Asthma: Potential Implication of Vascular Endothelial Growth Factor
Inflammation & Allergy - Drug Targets (Discontinued) Mast Cells in Lung Homeostasis: Beyond Type I Hypersensitivity
Current Respiratory Medicine Reviews Swertia chirata: A Comprehensive Review with Recent Advances
Current Pharmaceutical Biotechnology Noradrenergic System in Down Syndrome and Alzheimer’s Disease A Target for Therapy
Current Alzheimer Research Long-Term Benzodiazepine Use and Mortality: Are we Doing the Right Studies?
Current Drug Safety Monoamine Receptors in the Regulation of Feeding Behaviour and Energy Balance
CNS & Neurological Disorders - Drug Targets Development and Optimization of Press Coated Floating Pulsatile Drug Delivery of Sumatriptan Succinate
Current Drug Delivery Inappropriate Medication Use and Cost Comparison Analysis of Proton Pump Inhibitors: Evidence from an Indian Tertiary Care Facility
Current Drug Safety Anti-IgE Therapy in Allergic Asthma
Current Drug Targets - Inflammation & Allergy New Insights on Neuronal Nicotinic Acetylcholine Receptors as Targets for Pain and Inflammation: A Focus on α7 nAChRs
Current Neuropharmacology Hepatic PPARs: Their Role in Liver Physiology, Fibrosis and Treatment
Current Medicinal Chemistry Recent Advances and Perceptions in Studies of Heterodimerization between G Protein-Coupled Receptors
Protein & Peptide Letters Current Evaluation of the Millennium Phytomedicine- Ginseng (II): Collected Chemical Entities, Modern Pharmacology, and Clinical Applications Emanated from Traditional Chinese Medicine
Current Medicinal Chemistry Syk: A Novel Target for Treatment of Inflammation in Lung Disease
Inflammation & Allergy - Drug Targets (Discontinued) Editorial [ Hot Topic: State of the Science: Pediatric Asthma (Guest Editors: Barbara Velsor-Friedrich and Arlene Butz)]
Current Pediatric Reviews Correlations between the Youth Healthy Eating Index, Body Mass Index and the Salivary Nitric Oxide Concentration in Overweight/Obese Children
Endocrine, Metabolic & Immune Disorders - Drug Targets MicroRNAs as Diagnostic, Prognostic and Predictive Biomarkers of Ovarian Cancer
Recent Patents on Biomarkers Progress in Understanding Basal Ganglia Dysfunction as a Common Target for Methamphetamine Abuse and HIV-1 Neurodegeneration
Current HIV Research