Abstract
Periodontal disease initiation and progression occurs as a consequence of the host immune inflammatory response to oral pathogens. The innate and acquired immune systems are critical for the proper immune response. LPS, an outer membrane constituent of periodontal pathogenic bacteria, stimulates the production of inflammatory cytokines IL-1β, TNFα, IL-6 and RANKL either directly or indirectly. In LPS-stimulated cells, the induction of cytokine expression requires activation of several signaling pathways including the p38 MAPK pathway. This review will discuss the significance of the p38 MAPK pathway in periodontal disease progression and the potential therapeutic consequences of pharmacological antagonism of this pathway in the treatment of periodontal diseases.
Keywords: Periodontal diseases, p38 MAPK, p38 inhibitors, innate immunity, inflammation, bone loss, cytokine, experimental periodontitis
Current Drug Metabolism
Title: The Potential of p38 MAPK Inhibitors to Modulate Periodontal Infections
Volume: 10 Issue: 1
Author(s): Keith L. Kirkwood and Carlos Rossa, Jr.
Affiliation:
Keywords: Periodontal diseases, p38 MAPK, p38 inhibitors, innate immunity, inflammation, bone loss, cytokine, experimental periodontitis
Abstract: Periodontal disease initiation and progression occurs as a consequence of the host immune inflammatory response to oral pathogens. The innate and acquired immune systems are critical for the proper immune response. LPS, an outer membrane constituent of periodontal pathogenic bacteria, stimulates the production of inflammatory cytokines IL-1β, TNFα, IL-6 and RANKL either directly or indirectly. In LPS-stimulated cells, the induction of cytokine expression requires activation of several signaling pathways including the p38 MAPK pathway. This review will discuss the significance of the p38 MAPK pathway in periodontal disease progression and the potential therapeutic consequences of pharmacological antagonism of this pathway in the treatment of periodontal diseases.
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Cite this article as:
Kirkwood L. Keith and Rossa, Jr. Carlos, The Potential of p38 MAPK Inhibitors to Modulate Periodontal Infections, Current Drug Metabolism 2009; 10 (1) . https://dx.doi.org/10.2174/138920009787048347
DOI https://dx.doi.org/10.2174/138920009787048347 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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Interaction between drugs and endocrine diseases
The introduction of highly active antiretroviral therapy accelerated studies and our understanding on the interaction between pharmacological therapies and endocrine diseases. Drugs can precipitate endocrine via different mechanisms, including direct alteration of hormone production and secretion, dysregulation of hormonal axis, effects on hormonal transport, receptor-binding, and cellular signalling. Common drug-induced ...read more
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