Abstract
Long interspersed nuclear elements (LINEs) are mobile sequences shown to play a fundamental role in eukaryotic genome evolution. Recently, increasing interest has been directed at unveiling molecular mechanisms by which LINE-1 (L1), a ubiquitous member of this family, regulates gene expression and mammalian cell development, differentiation, and cancer. This mini review summarizes recent studies conducted to examine stress-induced L1 reactivation, with special attention given to the role of E2F/Rb transcription factors in epigenetic silencing of L1 and its potential role as a global modifier of chromatin structure and function. The last section focuses on the impact of histone deacetylase inhibitors in the regulation of gene function, chromatin structure, and cancer treatment through alterations in epigenetic signaling.
Keywords: Epigenetics, HDAC inhibitors, histone methylation, LINE-1, retinoblastoma
Current Molecular Medicine
Title: L1 Retrotransposon and Retinoblastoma: Molecular Linkages Between Epigenetics and Cancer
Volume: 10 Issue: 5
Author(s): D.E. Montoya-Durango and K.S. Ramos
Affiliation:
Keywords: Epigenetics, HDAC inhibitors, histone methylation, LINE-1, retinoblastoma
Abstract: Long interspersed nuclear elements (LINEs) are mobile sequences shown to play a fundamental role in eukaryotic genome evolution. Recently, increasing interest has been directed at unveiling molecular mechanisms by which LINE-1 (L1), a ubiquitous member of this family, regulates gene expression and mammalian cell development, differentiation, and cancer. This mini review summarizes recent studies conducted to examine stress-induced L1 reactivation, with special attention given to the role of E2F/Rb transcription factors in epigenetic silencing of L1 and its potential role as a global modifier of chromatin structure and function. The last section focuses on the impact of histone deacetylase inhibitors in the regulation of gene function, chromatin structure, and cancer treatment through alterations in epigenetic signaling.
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Cite this article as:
Montoya-Durango D.E. and Ramos K.S., L1 Retrotransposon and Retinoblastoma: Molecular Linkages Between Epigenetics and Cancer, Current Molecular Medicine 2010; 10 (5) . https://dx.doi.org/10.2174/156652410791608234
DOI https://dx.doi.org/10.2174/156652410791608234 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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