Abstract
Iron imbalance plays a pivotal role in oxidative damages associated with a wide range of pathological conditions. However, owing to the essential role of iron in biological processes, the beneficial effects of iron chelation therapy against oxidative damage have to be balanced against potential toxicity. The present review briefly introduces iron redox biochemistry and oxidative-stress associated pathologies, surveys recent advances in iron chelating strategies and summarizes some of our recent findings in this field, with a special emphasis on the chemical design constraints one must satisfy in order to synthesize iron chelators which could be beneficial against oxidative stress without inducing iron depletion of the body. The concept of oxidative stress activatable iron chelators is presented as a new paradigm for safe and efficient treatment of oxidative-stress associated conditions.
Keywords: Iron Chelators, Against Oxidative, oxidative stress, Iron, Post-ischaemic Reperfusion Injury, Atherosclerosis, Neurodegenerative Diseases
Mini-Reviews in Medicinal Chemistry
Title: Recent Advances in the Design of Iron Chelators Against Oxidative Damage
Volume: 1 Issue: 3
Author(s): J. B. Galey
Affiliation:
Keywords: Iron Chelators, Against Oxidative, oxidative stress, Iron, Post-ischaemic Reperfusion Injury, Atherosclerosis, Neurodegenerative Diseases
Abstract: Iron imbalance plays a pivotal role in oxidative damages associated with a wide range of pathological conditions. However, owing to the essential role of iron in biological processes, the beneficial effects of iron chelation therapy against oxidative damage have to be balanced against potential toxicity. The present review briefly introduces iron redox biochemistry and oxidative-stress associated pathologies, surveys recent advances in iron chelating strategies and summarizes some of our recent findings in this field, with a special emphasis on the chemical design constraints one must satisfy in order to synthesize iron chelators which could be beneficial against oxidative stress without inducing iron depletion of the body. The concept of oxidative stress activatable iron chelators is presented as a new paradigm for safe and efficient treatment of oxidative-stress associated conditions.
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Cite this article as:
Galey B. J., Recent Advances in the Design of Iron Chelators Against Oxidative Damage, Mini-Reviews in Medicinal Chemistry 2001; 1 (3) . https://dx.doi.org/10.2174/1389557013406846
DOI https://dx.doi.org/10.2174/1389557013406846 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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