Abstract
Patients with multiple sclerosis (MS) often suffer from cognitive dysfunction; the underlying mechanisms have not been fully elucidated. Recent studies suggest that MS leads to heightened synaptic transmission and plasticity in different brain areas, and therefore may contribute to the observed behavioral abnormalities. Recent findings demonstrate synaptic plasticity changes in MS, including evidence from animal models of experimental autoimmune encephalomyelitis and human MS patients.
Keywords: Experimental autoimmune encephalomyelitis, inflammation, multiple sclerosis, N-methyl-D-aspartic acid, synaptic plasticity, trophic factor.
CNS & Neurological Disorders - Drug Targets
Title:Commentary (Changes of Synaptic Plasticity in Multiple Sclerosis)
Volume: 14 Issue: 2
Author(s): Ti-Fei Yuan, Chunlei Shan and Oscar Arias-Carrion
Affiliation:
Keywords: Experimental autoimmune encephalomyelitis, inflammation, multiple sclerosis, N-methyl-D-aspartic acid, synaptic plasticity, trophic factor.
Abstract: Patients with multiple sclerosis (MS) often suffer from cognitive dysfunction; the underlying mechanisms have not been fully elucidated. Recent studies suggest that MS leads to heightened synaptic transmission and plasticity in different brain areas, and therefore may contribute to the observed behavioral abnormalities. Recent findings demonstrate synaptic plasticity changes in MS, including evidence from animal models of experimental autoimmune encephalomyelitis and human MS patients.
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Cite this article as:
Yuan Ti-Fei, Shan Chunlei and Arias-Carrion Oscar, Commentary (Changes of Synaptic Plasticity in Multiple Sclerosis), CNS & Neurological Disorders - Drug Targets 2015; 14 (2) . https://dx.doi.org/10.2174/1871527313666141114203620
DOI https://dx.doi.org/10.2174/1871527313666141114203620 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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