Abstract
Pin1 is a unique peptidyl-prolyl cis/trans isomerase (PPIase) that catalyzes the cis/trans isomerization of peptidyl-prolyl peptide bonds of its substrate proteins by binding to their specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. This alters the conformation of target proteins and consequently affects their stability, intracellular localization, and/or biological functions. The abnormal overexpression of Pin1 is observed in some malignancies, which is associated with cancer cell proliferation, migration and invasion. However, a role for Pin1 as a putative tumor suppressor has recently been suggested. Systematic dissection of pro-oncogenic vs. tumor suppressive functions of Pin1 will be necessary.
Keywords: Pin1, proline-directed protein kinases, phosphorylation-dependent peptidyl-prolyl isomerase, pSer/Thr-Pro motif, PPIase, proline isomerization.
Current Pharmaceutical Design
Title:Dual Roles of Pin1 in Cancer Development and Progression
Volume: 23 Issue: 29
Author(s): Hyeong-jun Han, Bu Young Choi and Young-Joon Surh*
Affiliation:
- Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul 08826,Korea
Keywords: Pin1, proline-directed protein kinases, phosphorylation-dependent peptidyl-prolyl isomerase, pSer/Thr-Pro motif, PPIase, proline isomerization.
Abstract: Pin1 is a unique peptidyl-prolyl cis/trans isomerase (PPIase) that catalyzes the cis/trans isomerization of peptidyl-prolyl peptide bonds of its substrate proteins by binding to their specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. This alters the conformation of target proteins and consequently affects their stability, intracellular localization, and/or biological functions. The abnormal overexpression of Pin1 is observed in some malignancies, which is associated with cancer cell proliferation, migration and invasion. However, a role for Pin1 as a putative tumor suppressor has recently been suggested. Systematic dissection of pro-oncogenic vs. tumor suppressive functions of Pin1 will be necessary.
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Cite this article as:
Han Hyeong-jun , Choi Young Bu and Surh Young-Joon *, Dual Roles of Pin1 in Cancer Development and Progression, Current Pharmaceutical Design 2017; 23 (29) . https://dx.doi.org/10.2174/1381612823666170703164711
DOI https://dx.doi.org/10.2174/1381612823666170703164711 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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