Abstract
Sulfonamides are compounds with a broad spectrum of biological applications, and can act as potential medicinal molecules in drug discovery and drug development. Numerous sulfonamide-based molecules can be used to develop potent lead compounds with better efficacy and less toxicity. This review focuses on the latest information pertaining to sulfonamide derivatives having different pharmacological properties including anticancer, antiviral, antimicrobial, antibacterial, antifungal, antiinflammatory, antituberculosis, carbonic anhydrase inhibition, antimalarial, antiparasitic, anticonvulsant, and antidepressant activities, as well as carbonic anhydrase inhibitors. Relevant references have been obtained from MEDLINE (PubMed), Google Scholar, ScienceDirect, Cochrane, Scopus, SID, SciFinder, and ISI Web of Knowledge. This review article provides a literature overview of the various biological activities of sulfonamides, and covers the related literature from the last decade. It also briefly describes the therapeutic importance of sulfonamide derivatives and their pharmacological applications in a concise manner.
Keywords: Sulfonamide, anticancer, antimicrobial, antiinflammatory, antiviral, pharmacology.
Current Organic Chemistry
Title:Sulfonamides as Potential Bioactive Scaffolds
Volume: 22 Issue: 8
Author(s): Farhan A. Khan*, Sidra Mushtaq, Sadia Naz, Umar Farooq, Asma Zaidi, Syed Majid Bukhari, Abdur Rauf*Mohammad S. Mubarak*
Affiliation:
- Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, KPK,Pakistan
- Department of Chemistry, University of Swabi, Ambar-23561, KPK,Pakistan
- Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, KPK,Pakistan
Keywords: Sulfonamide, anticancer, antimicrobial, antiinflammatory, antiviral, pharmacology.
Abstract: Sulfonamides are compounds with a broad spectrum of biological applications, and can act as potential medicinal molecules in drug discovery and drug development. Numerous sulfonamide-based molecules can be used to develop potent lead compounds with better efficacy and less toxicity. This review focuses on the latest information pertaining to sulfonamide derivatives having different pharmacological properties including anticancer, antiviral, antimicrobial, antibacterial, antifungal, antiinflammatory, antituberculosis, carbonic anhydrase inhibition, antimalarial, antiparasitic, anticonvulsant, and antidepressant activities, as well as carbonic anhydrase inhibitors. Relevant references have been obtained from MEDLINE (PubMed), Google Scholar, ScienceDirect, Cochrane, Scopus, SID, SciFinder, and ISI Web of Knowledge. This review article provides a literature overview of the various biological activities of sulfonamides, and covers the related literature from the last decade. It also briefly describes the therapeutic importance of sulfonamide derivatives and their pharmacological applications in a concise manner.
Export Options
About this article
Cite this article as:
Khan A. Farhan *, Mushtaq Sidra , Naz Sadia , Farooq Umar , Zaidi Asma , Bukhari Majid Syed , Rauf Abdur *, Mubarak S. Mohammad *, Sulfonamides as Potential Bioactive Scaffolds, Current Organic Chemistry 2018; 22 (8) . https://dx.doi.org/10.2174/1385272822666180122153839
DOI https://dx.doi.org/10.2174/1385272822666180122153839 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Development of Genomics-Based Gene Expression Signature Biomarkers in Oncology and Toxicology to Facilitate Drug Discovery and Translational Medicine
Current Bioinformatics Animal Models of Carcinogenesis in Inflamed Colorectum: Potential Use in Chemoprevention Study
Current Drug Targets APO2L/TRAIL: New Insights in the Treatment of Autoimmune Disorders
Recent Patents on Inflammation & Allergy Drug Discovery Non-Small Cell Lung Carcinoma: An Overview on Targeted Therapy
Current Drug Targets KRAB-Zinc Finger Proteins: A Repressor Family Displaying Multiple Biological Functions
Current Genomics An Overview of the α4β1 Integrin and the Potential Therapeutic Role of its Antagonists
Current Medicinal Chemistry Inhibitors of Apoptosis Proteins (IAPs) as Potential Molecular Targets for Therapy of Hematological Malignancies
Current Molecular Medicine Novel Targets for Apoptosis Modulation: BAG3 Protein and Other Co- Chaperones
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Ether Lipids as Anticancer Agents: Focus on Non-Phosphorus Cationic Glycerolipids
Mini-Reviews in Medicinal Chemistry Preclinical and Clinical Efficacy of the Bisphosphonate Ibandronate in Cancer Treatment
Current Clinical Pharmacology Molecular Mechanisms of Pancreatic Cancer Dissemination: The Role of the Chemokine System
Current Pharmaceutical Design Using Nutrigenomics to Evaluate Apoptosis as a Preemptive Target in Cancer Prevention
Current Cancer Drug Targets Omega-3 Polyunsaturated Fatty Acid Derived Lipid Mediators and their Application in Drug Discovery
Current Medicinal Chemistry A Stress Repair Mechanism That Maintains Vertebrate Structure During Stress
Cardiovascular & Hematological Disorders-Drug Targets Traditional Chinese Medicines (TCMs) for Molecular Targeted Therapies of Tumours
Current Drug Discovery Technologies Chronic Migraineurs Form Carboxyhemefibrinogen and Iron-Bound Fibrinogen
CNS & Neurological Disorders - Drug Targets Concentrations of Cd, Cu, Pb and Zn in Blood Serum of Cancer Patients and Comparison with Healthy Person by Atomic Absorption Spectrometry
Current Analytical Chemistry Bioactive Polyphenols from Grapes and Wine Emphasized with Resveratrol
Current Pharmaceutical Design Stimuli-Responsive Nanoparticles for siRNA Delivery
Current Pharmaceutical Design Peeking into the Black Box: How Cytokine Antibody Arrays Shed Light on Molecular Mechanisms of Breast Cancer Development and its Treatment
Current Proteomics