Abstract
The marine sponges are the source of a unique group of natural products featuring a novel skeleton, the two indole rings were directed linked by a central heterocyclic moiety. Since topsentin, a bis(indolyl)imidazole, and its analogues were isolated from Topsentia genitrix about a decade ago, scientists have isolated various novel bis(indole) alkaloids from marine organisms especially from deep-water sponges in succession. Over the last 15 years there has been an ever-increasing interest in the biological activity of these molecules. These studies became possible as a result of the scientific development of isolation, purification and total synthesis methods concomitant with the development of fairly simple in vitro tests. This paper offers a general view of the recent progress in the field of novel marine bis(indole) alkaloids, including the topsentins, nortopsentins, rhopaladins, hamacanthins, and dragmacidins family natural products. It focuses on the isolation, structure determination, and total synthesis of these bioactive alkaloids.
Keywords: chemistry, isolation, sponge, marine environment, anti-inflammatory activities, topsentins, synthesis
Current Organic Chemistry
Title: Progress in Studies of Novel Marine Bis(indole) Alkaloids
Volume: 8 Issue: 17
Author(s): Cai-Guang Yang, Hao Huang and Biao Jiang
Affiliation:
Keywords: chemistry, isolation, sponge, marine environment, anti-inflammatory activities, topsentins, synthesis
Abstract: The marine sponges are the source of a unique group of natural products featuring a novel skeleton, the two indole rings were directed linked by a central heterocyclic moiety. Since topsentin, a bis(indolyl)imidazole, and its analogues were isolated from Topsentia genitrix about a decade ago, scientists have isolated various novel bis(indole) alkaloids from marine organisms especially from deep-water sponges in succession. Over the last 15 years there has been an ever-increasing interest in the biological activity of these molecules. These studies became possible as a result of the scientific development of isolation, purification and total synthesis methods concomitant with the development of fairly simple in vitro tests. This paper offers a general view of the recent progress in the field of novel marine bis(indole) alkaloids, including the topsentins, nortopsentins, rhopaladins, hamacanthins, and dragmacidins family natural products. It focuses on the isolation, structure determination, and total synthesis of these bioactive alkaloids.
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Cite this article as:
Yang Cai-Guang, Huang Hao and Jiang Biao, Progress in Studies of Novel Marine Bis(indole) Alkaloids, Current Organic Chemistry 2004; 8 (17) . https://dx.doi.org/10.2174/1385272043369656
DOI https://dx.doi.org/10.2174/1385272043369656 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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