Abstract
The sensory contact model can induce various different psychopathological states in male mice (anxious depression, catalepsy, social withdrawal, pathological aggression, cognition disturbances, anhedonia, alcoholism etc.). Additionally, this model facilitates the screening of drugs for therapeutic properties, preventive properties and efficiency under simulated clinical conditions. This approach can reveal the action of drugs at different stages of disease development. It is proposed that this pharmacological approach can be applied for the screening of various novel psychotropic drugs.
Keywords: Sensory contact model, psychotropic drugs, screening
Current Drug Metabolism
Title: An Experimental Approach for the Study of Psychotropic Drug Effects Under Simulated Clinical Conditions
Volume: 9 Issue: 4
Author(s): N. N. Kudryavtseva, D. F. Avgustinovich, N. P. Bondar, M. V. Tenditnik and I. L. Kovalenko
Affiliation:
Keywords: Sensory contact model, psychotropic drugs, screening
Abstract: The sensory contact model can induce various different psychopathological states in male mice (anxious depression, catalepsy, social withdrawal, pathological aggression, cognition disturbances, anhedonia, alcoholism etc.). Additionally, this model facilitates the screening of drugs for therapeutic properties, preventive properties and efficiency under simulated clinical conditions. This approach can reveal the action of drugs at different stages of disease development. It is proposed that this pharmacological approach can be applied for the screening of various novel psychotropic drugs.
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Kudryavtseva N. N., Avgustinovich F. D., Bondar P. N., Tenditnik V. M. and Kovalenko L. I., An Experimental Approach for the Study of Psychotropic Drug Effects Under Simulated Clinical Conditions, Current Drug Metabolism 2008; 9 (4) . https://dx.doi.org/10.2174/138920008784220592
DOI https://dx.doi.org/10.2174/138920008784220592 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
Call for Papers in Thematic Issues
Interaction between drugs and endocrine diseases
The introduction of highly active antiretroviral therapy accelerated studies and our understanding on the interaction between pharmacological therapies and endocrine diseases. Drugs can precipitate endocrine via different mechanisms, including direct alteration of hormone production and secretion, dysregulation of hormonal axis, effects on hormonal transport, receptor-binding, and cellular signalling. Common drug-induced ...read more
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