Abstract
Our understanding of the process of translation has progressed rapidly since the availability of highly resolved structures for the ribosome. A wealth of information has emerged in terms of both RNA and protein structure and the interplay between them. This has prompted us to revisit the astonishing “treasure trove” of functional data regarding the ribosome that has accumulated over the past decades. Here we try a systematic synopsis of these ribosomal functions in light of the cryo-electron microscopic structures (resolution > 7 Å) and the atomic x-ray structures ( > 2.4 Å) of the ribosome.
Keywords: Protein Synthesis, Atomic Resolution, Ribosome, translation, haloarcula marismortui, bacillus stearothermophilus, Translocation, thermus aquaticus, ribosome recycling
Current Protein & Peptide Science
Title: Protein Synthesis at Atomic Resolution: Mechanistics of Translation in the Light of Highly Resolved Structures for the Ribosome
Volume: 3 Issue: 1
Author(s): Daniel N. Wilson, Gregor Blaha, Sean R. Connell, Pavel V. Ivanov, Holger Jenke, Ulrich Stelzl, Yoshika Teraoka and Knud H. Nierhaus
Affiliation:
Keywords: Protein Synthesis, Atomic Resolution, Ribosome, translation, haloarcula marismortui, bacillus stearothermophilus, Translocation, thermus aquaticus, ribosome recycling
Abstract: Our understanding of the process of translation has progressed rapidly since the availability of highly resolved structures for the ribosome. A wealth of information has emerged in terms of both RNA and protein structure and the interplay between them. This has prompted us to revisit the astonishing “treasure trove” of functional data regarding the ribosome that has accumulated over the past decades. Here we try a systematic synopsis of these ribosomal functions in light of the cryo-electron microscopic structures (resolution > 7 Å) and the atomic x-ray structures ( > 2.4 Å) of the ribosome.
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Cite this article as:
Wilson N. Daniel, Blaha Gregor, Connell R. Sean, Ivanov V. Pavel, Jenke Holger, Stelzl Ulrich, Teraoka Yoshika and Nierhaus H. Knud, Protein Synthesis at Atomic Resolution: Mechanistics of Translation in the Light of Highly Resolved Structures for the Ribosome, Current Protein & Peptide Science 2002; 3 (1) . https://dx.doi.org/10.2174/1389203023380846
DOI https://dx.doi.org/10.2174/1389203023380846 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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