摘要
内皮细胞-间质转化(EndMT)是使正常的内皮细胞获得间质表型,这种现象难以被人理解。 EndMT已经从癌症到纤维症再到心血管疾病等各种病理条件下进行了观察,该过程本身在这些疾病状态的发展中起到了重要的作用。
关键词: 内皮细胞;内皮细胞-间质转化;EndMT;转化生长因子-β;成纤维细胞生长因子
Current Drug Targets
Title:Future Targets in Endothelial Biology: Endothelial Cell to Mesenchymal Transition
Volume: 17 Issue: 15
Author(s): Pei-Yu Chen, Michael Simons
Affiliation:
关键词: 内皮细胞;内皮细胞-间质转化;EndMT;转化生长因子-β;成纤维细胞生长因子
摘要: Endothelial to mesenchymal transition (EndMT) is a poorly understood phenomenon that results in normal endothelial cells acquiring a mesenchymal phenotype. EndMT has been observed in a number of pathological conditions, from cancer to fibrosis to cardiovascular disease and the process itself may play an important mechanistic role in the development of these disease states.
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Cite this article as:
Pei-Yu Chen, Michael Simons , Future Targets in Endothelial Biology: Endothelial Cell to Mesenchymal Transition, Current Drug Targets 2016; 17 (15) . https://dx.doi.org/10.2174/1389450117666160502151308
DOI https://dx.doi.org/10.2174/1389450117666160502151308 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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