Abstract
Bioactive molecules such as peptides and proteins can optimize the repair of bone tissue; however, the results are often unpredictable when administered alone, owing to their short biological half-life and instability. Thus, the development of bioactive molecule-loaded drug delivery systems (DDS) to repair bone tissue has been the subject of intense research. DDS can optimize the repair of bone tissue owing to their physicochemical properties, which improve cellular interactions and enable the incorporation and prolonged release of bioactive molecules. These characteristics are fundamental to favor bone tissue homeostasis, since the biological activity of these factors depends on how accessible they are to the cell. Considering the importance of these DDS, this review aims to present relevant information on DDS when loaded with osteogenic growth peptide and bone morphogenetic protein. These are bioactive molecules that are capable of modulating the differentiation and proliferation of mesenchymal cells in bone tissue cells. Moreover, we will present different approaches using these peptide and protein-loaded DDS, such as synthetic membranes and scaffolds for bone regeneration, synthetic grafts, bone cements, liposomes, and micelles, which aim at improving the therapeutic effectiveness, and we will compare their advantages with commercial systems.
Keywords: Bioactive molecules, drug delivery systems, osteogenic growth peptide, bone morphogenetic protein, tissue repair.
Current Protein & Peptide Science
Title:Bioactive Molecule-loaded Drug Delivery Systems to Optimize Bone Tissue Repair
Volume: 18 Issue: 8
Author(s): Joao Augusto Oshiro , Mariana Rillo Sato, Cassio Rocha Scardueli, Guilherme Jose Pimentel Lopes de Oliveira, Marina Paiva Abucafy and Marlus Chorilli*
Affiliation:
- Faculdade de Ciências Farmacêuticas, UNESP-Univ Estadual Paulista, Araraquara-Jaú, Km 1, Araraquara, 14800-903 SP,Brazil
Keywords: Bioactive molecules, drug delivery systems, osteogenic growth peptide, bone morphogenetic protein, tissue repair.
Abstract: Bioactive molecules such as peptides and proteins can optimize the repair of bone tissue; however, the results are often unpredictable when administered alone, owing to their short biological half-life and instability. Thus, the development of bioactive molecule-loaded drug delivery systems (DDS) to repair bone tissue has been the subject of intense research. DDS can optimize the repair of bone tissue owing to their physicochemical properties, which improve cellular interactions and enable the incorporation and prolonged release of bioactive molecules. These characteristics are fundamental to favor bone tissue homeostasis, since the biological activity of these factors depends on how accessible they are to the cell. Considering the importance of these DDS, this review aims to present relevant information on DDS when loaded with osteogenic growth peptide and bone morphogenetic protein. These are bioactive molecules that are capable of modulating the differentiation and proliferation of mesenchymal cells in bone tissue cells. Moreover, we will present different approaches using these peptide and protein-loaded DDS, such as synthetic membranes and scaffolds for bone regeneration, synthetic grafts, bone cements, liposomes, and micelles, which aim at improving the therapeutic effectiveness, and we will compare their advantages with commercial systems.
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Cite this article as:
Oshiro Augusto Joao , Sato Rillo Mariana , Scardueli Rocha Cassio, de Oliveira Jose Pimentel Lopes Guilherme , Abucafy Paiva Marina and Chorilli Marlus*, Bioactive Molecule-loaded Drug Delivery Systems to Optimize Bone Tissue Repair, Current Protein & Peptide Science 2017; 18 (8) . https://dx.doi.org/10.2174/1389203718666170328111605
DOI https://dx.doi.org/10.2174/1389203718666170328111605 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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