Abstract
Vaccines represent the most successful and sustainable tactic to prevent and counteract infection. A vaccine generally improves immunity to a particular disease upon administration by inducing specific protective and efficient immune responses in all of the receiving population. The main known factors influencing the observed heterogeneity for immune responses induced by vaccines are gender, age, co-morbidity, immune system, and genetic background. This review is mainly focused on the genetic status effect to vaccine immune responses and how this could contribute to the development of novel vaccine candidates that could be better directed and predicted relative to the genetic history of an individual and/or population. The text offers a brief history of vaccinology as a field, a description of the genetic status of the most relevant and studied genes and their functionality and correlation with exposure to specific vaccines; followed by an inside look into autoimmunity as a concern when designing vaccines as well as perspectives and conclusions looking towards an era of personalized and predictive vaccinology instead of a one size fits all approach.
Keywords: Vaccine, Personalized medicine, Genetics, HLA, Autoimmune ecology, Infection, Autoimmunity and systems biology.
Current Genomics
Title:Genetics and Vaccines in the Era of Personalized Medicine
Volume: 16 Issue: 1
Author(s): John Castiblanco and Juan-Manuel Anaya
Affiliation:
Keywords: Vaccine, Personalized medicine, Genetics, HLA, Autoimmune ecology, Infection, Autoimmunity and systems biology.
Abstract: Vaccines represent the most successful and sustainable tactic to prevent and counteract infection. A vaccine generally improves immunity to a particular disease upon administration by inducing specific protective and efficient immune responses in all of the receiving population. The main known factors influencing the observed heterogeneity for immune responses induced by vaccines are gender, age, co-morbidity, immune system, and genetic background. This review is mainly focused on the genetic status effect to vaccine immune responses and how this could contribute to the development of novel vaccine candidates that could be better directed and predicted relative to the genetic history of an individual and/or population. The text offers a brief history of vaccinology as a field, a description of the genetic status of the most relevant and studied genes and their functionality and correlation with exposure to specific vaccines; followed by an inside look into autoimmunity as a concern when designing vaccines as well as perspectives and conclusions looking towards an era of personalized and predictive vaccinology instead of a one size fits all approach.
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Cite this article as:
Castiblanco John and Anaya Juan-Manuel, Genetics and Vaccines in the Era of Personalized Medicine, Current Genomics 2015; 16 (1) . https://dx.doi.org/10.2174/1389202916666141223220551
DOI https://dx.doi.org/10.2174/1389202916666141223220551 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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